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Titolo:
EFFECTS OF NMDA ON RESPIRATORY NEURONS IN NEWBORN RAT MEDULLA INVITRO
Autore:
KASHIWAGI M; ONIMARU H; HOMMA I;
Indirizzi:
SHOWA UNIV,SCH MED,DEPT PHYSIOL,1-5-8 HATANODAI,SHINAGAWA KU TOKYO 142 JAPAN SHOWA UNIV,SCH MED,DEPT PHYSIOL,1-5-8 HATANODAI,SHINAGAWA KU TOKYO 142 JAPAN
Titolo Testata:
Brain research bulletin
fascicolo: 1, volume: 32, anno: 1993,
pagine: 65 - 69
SICI:
0361-9230(1993)32:1<65:EONORN>2.0.ZU;2-2
Fonte:
ISI
Lingua:
ENG
Soggetto:
METHYL-D-ASPARTATE; SPINAL-CORD PREPARATION; RHYTHM-GENERATING NEURONS; FICTIVE LOCOMOTION; RECEPTORS; ACTIVATION; ANTAGONIST; GLUTAMATE; LAMPREY; MK-801;
Keywords:
NMDA; RESPIRATORY RHYTHM; PREINSPIRATORY NEURON; INSPIRATORY NEURON; VENTROLATERAL MEDULLA; INVITRO; NEWBORN RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M. Kashiwagi et al., "EFFECTS OF NMDA ON RESPIRATORY NEURONS IN NEWBORN RAT MEDULLA INVITRO", Brain research bulletin, 32(1), 1993, pp. 65-69

Abstract

In 30 brain stem-spinal cord preparations isolated from newborn rats,we examined effects of 10 muM N-methyl-D-asparate (NMDA) on 21 pre-inspiratory (Pre-I) and 26 inspiratory (1) neurons during perfusion in asynaptic blockade (low Ca2+, high Me2+) bath, referred to here as lowCa. Application of NMDA to 9 Pre-I neurons that burst rhythmically inlow Ca significantly increased the burst rates of 6. The activity of two Pre-I neurons out of four that fired tonically in low Ca, was changed to rhythmic bursts by NMDA. One of eight Pre-I neurons that were silent in low Ca was caused to burst rhythmically by NMDA. Application of NMDA had no effect on 20 1 neurons out of 26 tested. NMDA made one I neuron that was otherwise silent burst rhythmically in low Ca. The results suggest that, in this preparation, activation of NMDA receptorscould contribute to induction or facilitation of burst activity by respiratory neurons, especially Pre-I neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 02:22:26