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Titolo:
CEREBROSPINAL-FLUID APOLIPOPROTEIN-E LEVEL IS INCREASED IN LATE-ONSETALZHEIMERS-DISEASE
Autore:
MERCHED A; BLAIN H; VISVIKIS S; HERBETH B; JEANDEL C; SIEST G;
Indirizzi:
CNRS,URA 597,CTR MED PREVENT,2 RUE DU DOYEN JACQUES PARISOT F-54501 VANDOEUVRE NANCY FRANCE CNRS,URA 597,CTR MED PREVENT F-54501 VANDOEUVRE NANCY FRANCE CTR HOSP UNIV NANCY BRABOIS,SERV MED B F-54500 VANDOEUVRE NANCY FRANCE
Titolo Testata:
Journal of the neurological sciences
fascicolo: 1, volume: 145, anno: 1997,
pagine: 33 - 39
SICI:
0022-510X(1997)145:1<33:CALIII>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
E ALLELE EPSILON-4; AMYLOID-BETA; CHOLESTEROL; ASSOCIATION; PROTEIN; BRAIN; LIPOPROTEINS; PHENOTYPES; RECEPTOR; GENE;
Keywords:
NEUROLOGICAL DISEASES; ALZHEIMERS DISEASE (AD); APOLIPOPROTEIN E (APOE); CEREBROSPINAL FLUID (CSF);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
A. Merched et al., "CEREBROSPINAL-FLUID APOLIPOPROTEIN-E LEVEL IS INCREASED IN LATE-ONSETALZHEIMERS-DISEASE", Journal of the neurological sciences, 145(1), 1997, pp. 33-39

Abstract

Worldwide evidence has recently shown that the allele epsilon 4 of apolipoprotein E (ApoE) is a genetic risk factor for Alzheimer's disease(AD) underlining the possible role of apoE in the physiopathology of AD. To evaluate the usefulness of apoE concentration in pathogenesis of AD, we measured the cerebrospinal fluid (CSF) levels of apoE. CSF apoE level was significantly higher in 38 patients with late-onset AD than in 31 control patients and 47 patients suffering from other neurological and related diseases. Higher levels of CSF apoE were also present in a subset of patients with meningoencephalitis, motor neuron disease, and low back pain. The increase of CSF-apoE in AD is in agreement with results from studies that find an increase of mRNA apoE in the brains of AD patients. Compared to other works, these results underline the importance and the difficulties of the selection of the controls. The CSF apoE level seems to be a reflection of neuronal damage and/or an inflammatory reaction that may be common to AD and other neurological and related diseases. (C) 1997 Elsevier Science B.V.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/01/20 alle ore 18:36:58