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Titolo:
INFLUENCE OF FORMULATION VARIABLES ON PLASMA GROWTH-HORMONE LEVELS FOLLOWING INTRANASAL ADMINISTRATION OF GROWTH HORMONE-RELEASING PEPTIDE IN ANESTHETIZED RATS
Autore:
VORA JK; CHRISTENSEN GA; REGINATO MJ; MACIA RA; GOCHOCO CH; OH CK;
Indirizzi:
SMITHKLINE BEECHAM PHARMACEUT,DEPT PHARMACEUT SCI,POB 1539 KING OF PRUSSIA PA 19406 SMITHKLINE BEECHAM PHARMACEUT,DEPT PHARMACEUT SCI,POB 1539 KING OF PRUSSIA PA 19406 NORTHEASTERN UNIV,DEPT PHARMACEUT SCI BOSTON MA 02115 SMITHKLINE BEECHAM PHARMACEUT,DEPT REPROD TOXICOL KING OF PRUSSIA PA 19406
Titolo Testata:
Journal of controlled release
fascicolo: 1-3, volume: 24, anno: 1993,
pagine: 193 - 200
SICI:
0168-3659(1993)24:1-3<193:IOFVOP>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
ABSORPTION; HIS-D-TRP-ALA-TRP-D-PHE-LYS-NH2; DESMOPRESSIN; VISCOSITY; DELIVERY; INVITRO; DOGS;
Keywords:
INTRANASAL ADMINISTRATION; GROWTH HORMONE RELEASING PEPTIDE; FORMULATION; ABSORPTION; PHARMACOLOGICAL RESPONSE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
17
Recensione:
Indirizzi per estratti:
Citazione:
J.K. Vora et al., "INFLUENCE OF FORMULATION VARIABLES ON PLASMA GROWTH-HORMONE LEVELS FOLLOWING INTRANASAL ADMINISTRATION OF GROWTH HORMONE-RELEASING PEPTIDE IN ANESTHETIZED RATS", Journal of controlled release, 24(1-3), 1993, pp. 193-200

Abstract

Growth hormone releasing peptide (GHRP-6) is a synthetic hexapeptide that stimulates the release of growth hormone in several animal species. The feasibility of developing an efficacious intranasal formulationof GHRP-6 is currently under consideration for clinical and commercial applications. In this study, the influence of several formulation variables on growth hormone (GH) release following intranasal administration of GHRP-6 was examined in anesthetized rats. Pharmacologic availability of the peptide was significantly increased by reducing formulation tonicity (hypotonic solution) and incorporation of the preservative benzalkonium chloride. Alteration of formulation pH from 5 to 7 did not demonstrate significant changes in pharmacologic response. GH release decreased as solution viscosity was increased, suggesting a slowerrate of peptide absorption across the nasal epithelium.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 13:21:19