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Titolo:
IMAGING TUMOR HYPOXIA AND TUMOR PERFUSION
Autore:
GROSHAR D; MCEWAN AJB; PARLIAMENT MB; URTASUN RC; GOLBERG LE; HOSKINSON M; MERCER JR; MANNAN RH; WIEBE LI; CHAPMAN JD;
Indirizzi:
CROSS CANC INST,DEPT NUCL MED,11560 UNIV AVE EDMONTON T6G 1Z2 ALBERTACANADA CROSS CANC INST,DEPT NUCL MED,11560 UNIV AVE EDMONTON T6G 1Z2 ALBERTACANADA REBECCA SIEF GOVT HOSP SAFAD ISRAEL UNIV ALBERTA EDMONTON T6G 2E1 ALBERTA CANADA FOX CHASE CANC CTR PHILADELPHIA PA 19111
Titolo Testata:
The Journal of nuclear medicine
fascicolo: 6, volume: 34, anno: 1993,
pagine: 885 - 888
SICI:
0161-5505(1993)34:6<885:ITHATP>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
RADIATION-THERAPY; MARKER; SPECTROSCOPY; MISONIDAZOLE; CANCER;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
D. Groshar et al., "IMAGING TUMOR HYPOXIA AND TUMOR PERFUSION", The Journal of nuclear medicine, 34(6), 1993, pp. 885-888

Abstract

Tumor perfusion and oxygenation status have been suggested as factorswhich may influence treatment outcome in cancer patients. Nuclear medicine assays of tumor perfusion [Tc-99m-hexamethylpropylenamine oxime (HMPAO)] and tumor hypoxia [I-123-iodoazomycin arabinoside (IAZA)] have recently been developed and described. We report on measurements of perfusion and oxygenation status of 27 tumors in 22 patients using these probes. An inverse correlation between tumor uptake of HMPAO and IAZA was measured (p < 0.05), with severe perfusion deficit usually associated with an increased uptake of the hypoxic marker. This trend was observed for limited stage small-cell lung carcinoma, squamous-cell carcinoma of the head and neck, soft-tissue sarcoma, brain metastases from small-cell lung carcinoma and adenocarcinoma of the prostate as a group, but not for glioblastoma multiforme. Whereas each imaging agent can yield information about the physiological status of tumor and normal tissue, the information resulting from their combined use could be important in cancer therapy.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/01/20 alle ore 00:37:53