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Titolo:
OUTCOME OF CHILDHOOD EPILEPSY - A POPULATION-BASED STUDY WITH A SIMPLE PREDICTIVE SCORING SYSTEM FOR THOSE TREATED WITH MEDICATION
Autore:
CAMFIELD C; CAMFIELD P; GORDON K; SMITH B; DOOLEY J;
Indirizzi:
IZAAK WALTON KILLAM HOSP CHILDREN,BOX 3070 HALIFAX B3J 3G9 NS CANADA DALHOUSIE UNIV,DEPT PEDIAT HALIFAX B3H 4H2 NS CANADA DALHOUSIE UNIV,DEPT MATH HALIFAX B3H 4H2 NS CANADA
Titolo Testata:
The Journal of pediatrics
fascicolo: 6, volume: 122, anno: 1993,
pagine: 861 - 868
SICI:
0022-3476(1993)122:6<861:OOCE-A>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
1ST UNPROVOKED SEIZURE; NEONATAL SEIZURES; REGRESSION-MODEL; FIT TESTS; PROGNOSIS; CHILDREN; REMISSION; GOODNESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
C. Camfield et al., "OUTCOME OF CHILDHOOD EPILEPSY - A POPULATION-BASED STUDY WITH A SIMPLE PREDICTIVE SCORING SYSTEM FOR THOSE TREATED WITH MEDICATION", The Journal of pediatrics, 122(6), 1993, pp. 861-868

Abstract

A population-based study was conducted in on attempt to predict whichchild's epilepsy will remit. Use of data from a regional electroencephalography laboratory allowed identification of all children in Novo Scotia with epilepsy onset from 1977 through 1985 (excluding those withabsence and ''minor motor'' seizures). Children were followed for an average of 7 years. On the basis of clinical characteristics, a multivariate analysis was used to develop a scoring scheme to predict remission (defined as off medication at the end of the follow-up period). Survival curve methods were used to estimate the duration of medication treatment for those with remission. Of the 504 eligible patients, approximately 70% become seizure free long enough to discontinue medication. Approximately 70% of those stopping medication o first time remained seizure free. At the end of follow-up, 55% of the total cohort were in remission. At diagnosis, the best predictors of remission were age <12 years at onset, normol intelligence, no prior neonatal seizures, and fewer than 21 seizures before treatment. If predicted to have a remission, then, on the basis of survival curve analysis, 80% were without medication 100 months after diagnosis. After 12 months of treatment,prediction was enhanced by including a score for the number of seizures between 6 and 12 months on treatment. We conclude that approximately 55% of childhood epilepsy will remit. Our scoring system predicts reasonably accurately who will have a remission and when medication is likely to be discontinued.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/11/20 alle ore 21:26:48