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Titolo:
RENAL MORPHOLOGICAL-CHANGES AFTER SINOAORTIC DENERVATION IN DOGS
Autore:
ORFILA C; DAMASEMICHEL C; LEPERT JC; MONTASTRUC JL; SUC JM; MONTASTRUC P; GIROLAMI JP;
Indirizzi:
CHU RANGUEIL,INSERM,CJF 9107,1 AVE JEAN POUILLES F-31052 TOULOUSE FRANCE INSERM,U133 TOULOUSE FRANCE INSERM,PHARMACOL MED & CLIN LAB TOULOUSE FRANCE
Titolo Testata:
Hypertension
fascicolo: 6, volume: 21, anno: 1993,
parte:, 1
pagine: 758 - 766
SICI:
0194-911X(1993)21:6<758:RMASDI>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
SPONTANEOUSLY HYPERTENSIVE RAT; SYMPATHO-ADRENAL SYSTEM; URINARY KALLIKREIN; BLOOD-PRESSURE; BARORECEPTOR REFLEX; CONSCIOUS DOGS; ARTERIAL; CATECHOLAMINES; ADRENOCEPTORS; LESIONS;
Keywords:
HYPERTENSION, EXPERIMENTAL; DOG STUDIES; MICROSCOPY, ELECTRON; KIDNEY; DENERVATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
51
Recensione:
Indirizzi per estratti:
Citazione:
C. Orfila et al., "RENAL MORPHOLOGICAL-CHANGES AFTER SINOAORTIC DENERVATION IN DOGS", Hypertension, 21(6), 1993, pp. 758-766

Abstract

The present study investigates morphological renal lesions in sinoaortic-denervated dogs 1 (n = 6) and 18 (n = 5) months after sinoaortic denervation compared with sham-operated controls (n = 8). After 1 month, a marked hyalinization and moderate thickening of the media of arterioles and small interlobular arteries were observed. These changes associated with edema and intimal thickening led to a narrowing of the lumen. In glomeruli, increase of mesangial matrix was focally present inall cases and associated with mesangial proliferation. In four of sixcases, some glomeruli appeared retracted, with a large urinary space. A focal area of interstitial fibrosis occurred in just one case. After 18 months, similar but more pronounced vascular lesions were present, with marked hyperplasia of the media. Glomerular changes were characterized by mesangial lesions associated with focal glomerular sclerosis and thickening of Bowman's capsule. Tubulointerstitial lesions were more prominent in this group, with the presence of tubular epithelial changes and casts. Focal interstitial fibrosis, infiltrates, or both were demonstrated in all cases. These morphological lesions were associated with an increase in arterial blood pressure, proteinuria, and natriuresis and a decrease in urinary kallikrein. These results show thatchronic sinoaortic denervation in dogs is associated with renal lesions similar to those observed in other well-established experimental and clinical hypertensive states.

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Documento generato il 30/11/20 alle ore 00:38:17