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Titolo:
FLAVONE ACETIC-ACID (FAA) WITH RECOMBINANT INTERLEUKIN-2 (RIL-2) IN ADVANCED MALIGNANT MELANOMA-IV - PHARMACOKINETICS AND TOXICITY OF FLAVONE ACETIC-ACID AND ITS METABOLITES
Autore:
STRATFORD MRL; RUSTIN GJS; DENNIS MF; WATFA RR; HOWELLS N; OREILLY SM;
Indirizzi:
MT VERNON HOSP,CANC RES CAMPAIGN,GRAY LAB NORTHWOOD HA6 2JR MIDDX ENGLAND CHARING CROSS HOSP,DEPT MED ONCOL,CANC RES CAMPAIGN LABS LONDON W2 8RF ENGLAND MT VERNON HOSP,CTR REG CANC NORTHWOOD HA6 2JR MIDDX ENGLAND
Titolo Testata:
British Journal of Cancer
fascicolo: 6, volume: 67, anno: 1993,
pagine: 1351 - 1355
SICI:
0007-0920(1993)67:6<1351:FA(WRI>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
DOSE-DEPENDENT PHARMACOKINETICS; MICE; NSC-347512; CANCER; HUMANS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
13
Recensione:
Indirizzi per estratti:
Citazione:
M.R.L. Stratford et al., "FLAVONE ACETIC-ACID (FAA) WITH RECOMBINANT INTERLEUKIN-2 (RIL-2) IN ADVANCED MALIGNANT MELANOMA-IV - PHARMACOKINETICS AND TOXICITY OF FLAVONE ACETIC-ACID AND ITS METABOLITES", British Journal of Cancer, 67(6), 1993, pp. 1351-1355

Abstract

Flavone acetic acid (FAA) was administered at a dose of 4.8 g m-2 over 1 h to patients with advanced malignant disease in combination with Interleukin II. A new high performance liquid chromatography method isdescribed to determine both the parent compound and eight drug-related products, and the conditions required to determine these components in plasma are discussed. The half-life over the first 8 h was 2.3 h, but the terminal clearance of the drug was extremely slow. Severe (WHO Grade 4) hypotension was observed in some patients. However, incidenceof this did not appear to be associated with any differences in FAA plasma concentrations, nor were there differences in FAA clearance between those patients whose tumour responded to the drug combination and those who did not.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 21:36:03