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Titolo:
FLAVONE ACETIC-ACID (FAA) WITH RECOMBINANT INTERLEUKIN-2 (RIL-2) IN ADVANCED MALIGNANT-MELANOMA .1. CLINICAL AND VASCULAR STUDIES
Autore:
OREILLY SM; RUSTIN GJS; FARMER K; BURKE M; HILL S; DENEKAMP J;
Indirizzi:
CHARING CROSS HOSP,DEPT MED ONCOL LONDON W6 8RF ENGLAND CHARING CROSS HOSP,DEPT MED ONCOL LONDON W6 8RF ENGLAND MT VERNON HOSP,MT VERNON CTR CANC TREATMENT NORTHWOOD HA6 2RN MIDDX ENGLAND MT VERNON HOSP,CANC RES CAMPAIGN,GRAY LAB NORTHWOOD HA6 2RN MIDDX ENGLAND MT VERNON HOSP,DEPT HISTOPATHOL NORTHWOOD HA6 2RN MIDDX ENGLAND
Titolo Testata:
British Journal of Cancer
fascicolo: 6, volume: 67, anno: 1993,
pagine: 1342 - 1345
SICI:
0007-0920(1993)67:6<1342:FA(WRI>2.0.ZU;2-W
Fonte:
ISI
Lingua:
ENG
Soggetto:
TUMOR-NECROSIS-FACTOR; ANTITUMOR-ACTIVITY; PHASE-II; NSC-347512; CANCER; MICE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
S.M. Oreilly et al., "FLAVONE ACETIC-ACID (FAA) WITH RECOMBINANT INTERLEUKIN-2 (RIL-2) IN ADVANCED MALIGNANT-MELANOMA .1. CLINICAL AND VASCULAR STUDIES", British Journal of Cancer, 67(6), 1993, pp. 1342-1345

Abstract

A trial of FAA and rIL-2 has been performed both to study the clinical efficacy of this combination and to determine whether they cause haemorrhagic necrosis by acting upon tumour vasculature. FAA and rIL-2 were given to 23 patients with progressing metastatic melanoma. FAA 4.8 gm m-2 was given as a 1 h infusion without urine alkalinisation on days 1, 8 and 15. rIL-2 (6-18 x 10(6) iu/m2/day) was given as a continuous infusion days 8-12 and 15-19 (nine patients) or days 8-12 only (14 patients). Treatment was repeated after 2 weeks unless there was disease progression. Of the 21 assessable patients there have been one complete (skin and liver) and two partial responses (skin and liver, skin and nodes) lasting 20 + 17 + and 15 months, overall response rate 14%. Unexpectedly severe hypotension after the third FAA, when given 2-4 days after RIL-2, was the major toxicity (8/15 grade 3 or 4). No alteration in coagulation parameters were seen during therapy of the first ten patients. No increase in tumour necrosis was seen in any of the 15 biopsies taken from ten patients after therapy. This suggests that FAA does not have similar vascular effects in human as it does in murine tumours.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 26/11/20 alle ore 19:47:13