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Titolo:
SERUM INTERLEUKIN-6 LEVELS AS AN INDICATOR OF ACUTE REJECTION AFTER LIVER-TRANSPLANTATION IN CYNOMOLOGOUS MONKEYS
Autore:
OHZATO H; MONDEN M; YOSHIZAKI K; GOTOH M; KANAI T; UMESHITA K; TONO T; NISHIMOTO N; KISHIMOTO T; MORI T;
Indirizzi:
OSAKA UNIV,SCH MED,DEPT SURG 2,1-1-50 FUKUSHIMA,FUKUSHIMA KU OSAKA 553 JAPAN OSAKA UNIV,SCH MED,DEPT SURG 2,1-1-50 FUKUSHIMA,FUKUSHIMA KU OSAKA 553 JAPAN
Titolo Testata:
SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY
fascicolo: 6, volume: 23, anno: 1993,
pagine: 521 - 527
SICI:
0941-1291(1993)23:6<521:SILAAI>2.0.ZU;2-O
Fonte:
ISI
Lingua:
ENG
Keywords:
SERUM IL-6; ACUTE REJECTION; LIVER TRANSPLANTATION; CYNOMOLGUS MONKEYS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
NO
Recensione:
Indirizzi per estratti:
Citazione:
H. Ohzato et al., "SERUM INTERLEUKIN-6 LEVELS AS AN INDICATOR OF ACUTE REJECTION AFTER LIVER-TRANSPLANTATION IN CYNOMOLOGOUS MONKEYS", SURGERY TODAY-THE JAPANESE JOURNAL OF SURGERY, 23(6), 1993, pp. 521-527

Abstract

This study was designed to evaluate whether the sequential monitoringof serum interleukin-6 levels (SIL-6) could be helpful for diagnosingthe occurrence of hepatic allograft rejection. An SIL-6 post-transplant study was conducted on nine cynomolgus monkeys which had undergone orthotopic hepatic allotransplantation, six of which were treated withFK-506 (a new immunosuppressant agent isolated from Streptomyces tsukubaensis) and three of which were not. All the nontreated animals showed biochemical abnormalities from days 5-6, characterized by a marked elevation of serum alkaline phosphatase levels, and they eventually died on days 8, 12, and 63 (group I). Acute cellular rejection was confirmed by histological study of the hepatic grafts taken at autopsy or biopsy. On the other hand, four of the treated animals (group IIa) survived more than 30 days. Biochemical examination of this group showed no abnormal signs apart from a slight elevation of alkaline phosphatase(<2000 IU/l). Histological examination carried out around 30 days after transplantation revealed a transient infiltration of polynuclear cells into Glisson's area, with the portal vein and bile duct remaining intact. The remaining two animals (group IIb) died of dehydration and arterial thrombosis on days 5 and 7, respectively. A kinetic study of SIL-6 conducted during the first 2 weeks showed quite different patterns among the three groups. All recipients in group I demonstrated two peaks following grafting on days 1 and 3 or 4, the second peak of above 2.0 U/ml preceding biochemical abnormalities by 2 to 3 days. Conversely, the recipients in group IIa showed a single peak of SIL-6 on day 1, followed by a decrease to less than 2.0 U/ml. Group IIb characteristically showed a high level of SIL-6 on day 1, after which the value remained over 2.0 U/ml. In conclusion, the monitoring of SIL-6 proved useful for detecting the acute rejection of hepatic allografts, the recipients with rejected grafts displaying two peaks of SIL-6 after grafting. The first increment was observed on day 1, which might reflect the stress of the surgical procedure, while the second transient increment of SIL-6, observed on day 3 or 4, might suggest acute hepatic rejection, preceding biochemical abnormalities by 2 to 3 days.

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Documento generato il 12/07/20 alle ore 06:32:17