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Titolo:
A DIAGNOSTIC AND THERAPEUTIC N-OF-1 RANDOMIZED TRIAL
Autore:
COOK DJ; GUYATT GH; DAVIS C; WILLAN A; MCILROY W;
Indirizzi:
MCMASTER UNIV,FAC HLTH SCI,DEPT MED HAMILTON L8S 4L8 ONTARIO CANADA MCMASTER UNIV,FAC HLTH SCI,DEPT CLIN EPIDEMIOL & BIOSTAT HAMILTON L8S4L8 ONTARIO CANADA HAMILTON CIVIC HOSP,DEPT MED,DIV GEN HAMILTON ON CANADA SUNNYBROOK MED CTR,CTR STUDIES AGING TORONTO ON CANADA
Titolo Testata:
Canadian journal of psychiatry
fascicolo: 4, volume: 38, anno: 1993,
pagine: 251 - 254
SICI:
0706-7437(1993)38:4<251:ADATNR>2.0.ZU;2-K
Fonte:
ISI
Lingua:
ENG
Soggetto:
INDIVIDUAL PATIENTS; CLINICAL USEFULNESS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Social Sciences Citation Index
Science Citation Index Expanded
Citazioni:
7
Recensione:
Indirizzi per estratti:
Citazione:
D.J. Cook et al., "A DIAGNOSTIC AND THERAPEUTIC N-OF-1 RANDOMIZED TRIAL", Canadian journal of psychiatry, 38(4), 1993, pp. 251-254

Abstract

The objective of this paper is to study the effect of amitriptyline on a young woman with symptoms of lightheadedness, palpitations, somnolence and fatigue. We conducted a single case (N-of-1) randomized trialincluding three pairs of treatment periods. Each pair included one four-week period when the patient was receiving amitriptyline and one four-week period when the patient was receiving placebo. The clinical setting was a secondary care internal medicine practice. During active treatment periods, amitriptyline was given in a dose of 100 mg each evening. Efficacy symptoms included lightheadedness, headaches and somnolence/fatigue. Side-effects of dry mouth and constipation were also monitored. Each symptom was rated on a seven point scale in which higher numbers denoted fewer symptoms. For the combined efficacy score, the mean difference in scores and the associated standard error was in favour of amitriptyline. The most profound effect was on sleepiness. Thesedifferences represent clinically important treatment effects. Dry mouth and constipation were worse on the active drug, but differences didnot reach statistical significance. Our experience suggests the usefulness of N-of-1 randomized trials in outpatient me&cal practice, including psychiatric practice.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 13:39:00