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Titolo: ALPHA-METHYL-P-TYROSINE REDUCES POLY I-C-INDUCED AUGMENTING INTERFERON-PRODUCTION AND SPLENIC NATURAL-KILLER-CELL ACTIVITY IN MICE
Autore: WON SJ; LIN MT;
- Indirizzi:
- NATL CHENG KUNG UNIV,COLL MED,DEPT PHYSIOL TAINAN 70101 TAIWAN NATL CHENG KUNG UNIV,COLL MED,DEPT PHYSIOL TAINAN 70101 TAIWAN NATL CHENG KUNG UNIV,COLL MED,DEPT PHYSIOL TAINAN TAIWAN
- Titolo Testata:
- Pharmacology
fascicolo: 6,
volume: 46,
anno: 1993,
pagine: 332 - 340
- SICI:
- 0031-7012(1993)46:6<332:ARPIAI>2.0.ZU;2-B
- Fonte:
- ISI
- Lingua:
- ENG
- Soggetto:
- SYMPATHETIC NERVOUS-SYSTEM; MURINE LYMPHOCYTES; IMMUNE-RESPONSE; PROTEIN-KINASE; SPLEEN; INNERVATION; THYMUS; 6-HYDROXYDOPAMINE; RECEPTORS; INDUCTION;
- Keywords:
- ALPHA-METHYL-P-TYROSINE; INTERFERON; NATURAL KILLER CELLS; POLY I-C;
- Tipo documento:
- Article
- Natura:
- Periodico
- Settore Disciplinare:
- Science Citation Index Expanded
- Citazioni:
- 39
- Recensione:
- Indirizzi per estratti:
-
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- Citazione:
- S.J. Won e M.T. Lin, "ALPHA-METHYL-P-TYROSINE REDUCES POLY I-C-INDUCED AUGMENTING INTERFERON-PRODUCTION AND SPLENIC NATURAL-KILLER-CELL ACTIVITY IN MICE", Pharmacology, 46(6), 1993, pp. 332-340
Abstract
The present investigation was designed to extend our previous observations that alpha-methyl-p-tyrosine (AMPT; an inhibitor of norepinephrine synthesis) reduced splenic natural killer (NK) cell activity and totest whether NK augmentation or augmenting interferon (IFN) production induced by polyriboinosinic acid:polyribocytidylic acid (poly I:C; an IFN inducer) can be attenuated by AMPT in mice. Therefore, in the current study, the effects of AMPT (300 mg/kg i.p.) on splenic NK activity or plasma titers of IFN-alpha+beta were assessed in inbred C57BL/6 mice. It was found that treatment with AMPT reduced both poly I:C induced serum IFN and splenic NK activity in a dose- and time-dependent manner. These results suggest that AMPT inhibits IFN production and decreases splenic NK activity in vivo.
ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:00:36