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Titolo:
ALPHA-METHYL-P-TYROSINE REDUCES POLY I-C-INDUCED AUGMENTING INTERFERON-PRODUCTION AND SPLENIC NATURAL-KILLER-CELL ACTIVITY IN MICE
Autore:
WON SJ; LIN MT;
Indirizzi:
NATL CHENG KUNG UNIV,COLL MED,DEPT PHYSIOL TAINAN 70101 TAIWAN NATL CHENG KUNG UNIV,COLL MED,DEPT PHYSIOL TAINAN 70101 TAIWAN NATL CHENG KUNG UNIV,COLL MED,DEPT PHYSIOL TAINAN TAIWAN
Titolo Testata:
Pharmacology
fascicolo: 6, volume: 46, anno: 1993,
pagine: 332 - 340
SICI:
0031-7012(1993)46:6<332:ARPIAI>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
SYMPATHETIC NERVOUS-SYSTEM; MURINE LYMPHOCYTES; IMMUNE-RESPONSE; PROTEIN-KINASE; SPLEEN; INNERVATION; THYMUS; 6-HYDROXYDOPAMINE; RECEPTORS; INDUCTION;
Keywords:
ALPHA-METHYL-P-TYROSINE; INTERFERON; NATURAL KILLER CELLS; POLY I-C;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
39
Recensione:
Indirizzi per estratti:
Citazione:
S.J. Won e M.T. Lin, "ALPHA-METHYL-P-TYROSINE REDUCES POLY I-C-INDUCED AUGMENTING INTERFERON-PRODUCTION AND SPLENIC NATURAL-KILLER-CELL ACTIVITY IN MICE", Pharmacology, 46(6), 1993, pp. 332-340

Abstract

The present investigation was designed to extend our previous observations that alpha-methyl-p-tyrosine (AMPT; an inhibitor of norepinephrine synthesis) reduced splenic natural killer (NK) cell activity and totest whether NK augmentation or augmenting interferon (IFN) production induced by polyriboinosinic acid:polyribocytidylic acid (poly I:C; an IFN inducer) can be attenuated by AMPT in mice. Therefore, in the current study, the effects of AMPT (300 mg/kg i.p.) on splenic NK activity or plasma titers of IFN-alpha+beta were assessed in inbred C57BL/6 mice. It was found that treatment with AMPT reduced both poly I:C induced serum IFN and splenic NK activity in a dose- and time-dependent manner. These results suggest that AMPT inhibits IFN production and decreases splenic NK activity in vivo.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 23/01/21 alle ore 10:00:36