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Titolo:
GLYCOSYLATION OF THE MAJOR HUMAN PNEUMOCYSTIS-CARINII SURFACE-ANTIGEN
Autore:
LUNDGREN B; KOCH C; MATHIESEN L; NIELSEN JO; HANSEN JES;
Indirizzi:
UNIV COPENHAGEN,HVIDOVRE HOSP,DEPT INFECT DIS & MICROBIOL 144 DK-2650HVIDOVRE DENMARK STATENS SERUM INST DK-2300 COPENHAGEN DENMARK
Titolo Testata:
APMIS. Acta pathologica, microbiologica et immunologica Scandinavica
fascicolo: 3, volume: 101, anno: 1993,
pagine: 194 - 200
SICI:
0903-4641(1993)101:3<194:GOTMHP>2.0.ZU;2-5
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLYCOPROTEINS; RECEPTOR; LECTINS; RAT; MACROPHAGES; PNEUMONIA; PROTEIN; BINDING; GP120; CELLS;
Keywords:
PNEUMOCYSTIS-CARINII; GLYCOSYLATION; HIGH MANNOSE; MICROHETEROGENEITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
B. Lundgren et al., "GLYCOSYLATION OF THE MAJOR HUMAN PNEUMOCYSTIS-CARINII SURFACE-ANTIGEN", APMIS. Acta pathologica, microbiologica et immunologica Scandinavica, 101(3), 1993, pp. 194-200

Abstract

It has recently been shown that the major rat P carinii surface antigen is important for initial host-organism attachment, possibly throughbinding to fibronectin, mannose-binding protein, or surfactant protein A. Since a carbohydrate/lectin interaction may be involved in adhesion, we undertook this study to characterize the glycosylation of the major human P carinii surface glycoprotein (gp95). We have used purified gp95 as a source of antigen, and in lectin binding and deglycosylation studies it was found that approximately 9% of gp95 consists of N-linked carbohydrates of mainly high-mannose and bisected complex-type glycans. Using a polyclonal antibody raised against purified gp95 and crossed affinoimmunoelectrophoresis and the lectins Con A and WGA, gp95 exhibited carbohydrate-dependent microheterogeneity. We therefore suggest that gp95 is composed of subtypes which differ in N-linked glycosylation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/12/20 alle ore 19:53:11