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Titolo:
MODE OF INHIBITION OF RESPIRATOR SYNCYTIAL VIRUS BY A PLANT FLAVONOID, SP-303
Autore:
BARNARD DL; HUFFMAN JH; MEYERSON LR; SIDWELL RW;
Indirizzi:
UTAH STATE UNIV,INST ANTIVIRAL RES,DEPT ADVS LOGAN UT 84322 SHAMAN PHARMACEUT INC SAN CARLOS CA 00000
Titolo Testata:
Chemotherapy
fascicolo: 3, volume: 39, anno: 1993,
pagine: 212 - 217
SICI:
0009-3157(1993)39:3<212:MOIORS>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Soggetto:
PROTEIN; REPLICATION; INFECTION;
Keywords:
RESPIRATORY SYNCYTIAL VIRUS; ANTIVIRAL; SP-303; FLAVONOID; MECHANISM; PENETRATION; PLANT; NATURAL PRODUCT; EUPHORBIACEAE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Barnard et al., "MODE OF INHIBITION OF RESPIRATOR SYNCYTIAL VIRUS BY A PLANT FLAVONOID, SP-303", Chemotherapy, 39(3), 1993, pp. 212-217

Abstract

A natural-product polyphenolic polymer of molecular weight 2,100 daltons designated SP-303, was found to have antiviral activity against respiratory syncytial virus (RSV) in the 2-10 muM range in plaque reduction assays and cytopathic-effect-inhibition assays. The material was also virucidal. The 50% effective concentration (EC50) for virucidal activity was 28 muM. Experiments were done to determine the mode(s) of RSV inhibition by SP-303. Interferon was not induced. SP-303 did not inhibit attachment at antiviral concentrations. However, the EC50 for inhibition of virus penetration by SP-303 was 0.48 +/- 0.19 muM. These data suggest that abolition of RSV penetration into host cells is one mechanism whereby SP-303 inhibits RSV replication.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 09/08/20 alle ore 23:28:38