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Titolo:
ANTIHERPESVIRUS ACTIVITY AND MODE OF ACTION OF SP-303, A NOVEL PLANT FLAVONOID
Autore:
BARNARD DL; SMEE DF; HUFFMAN JH; MEYERSON LR; SIDWELL RW;
Indirizzi:
UTAH STATE UNIV,INST ANTIVIRAL RES,DEPT ADVS LOGAN UT 84322 SHAMAN PHARMACEUT INC SAN CARLOS CA 00000
Titolo Testata:
Chemotherapy
fascicolo: 3, volume: 39, anno: 1993,
pagine: 203 - 211
SICI:
0009-3157(1993)39:3<203:AAAMOA>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
SIMPLEX; INHIBITION; ACYCLOVIR;
Keywords:
HERPES SIMPLEX; HSV-2, FLAVONOID; SP-303; MECHANISM; ANTIVIRAL; EUPHORBIACEAE; PLANT; PENETRATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Barnard et al., "ANTIHERPESVIRUS ACTIVITY AND MODE OF ACTION OF SP-303, A NOVEL PLANT FLAVONOID", Chemotherapy, 39(3), 1993, pp. 203-211

Abstract

SP-303, a natural plant flavonoid polymer of molecular weight 2,100 daltons, was found to have antiviral activity against two strains of type 1 herpes-type simplex virus, including a thymidine-kinase-deficientstrain, and a strain of type 2 herpes simplex virus. The 50% effective concentrations (EC50s) were 1-2 muM. Acyclovir, which was run in parallel, had values of 4-28 muM. Surprisingly, the compound was inactiveagainst human cytomegalovirus. SP-303 was also virucidal at 50 muM. Interferon was not induced. The mode of antiviral action of this biopolymer was through inhibition of virus penetration into cells (EC50 = 2.1 +/- 0.2 muM). SP-303 also significantly reduced lesion formation in a mouse vaginal model when applied topically at 5-10%.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 11/07/20 alle ore 06:15:53