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Titolo:
OPIOID AND SUBSTANCE-P RECEPTOR ADAPTATIONS IN THE RAT SPINAL-CORD FOLLOWING SUBCHRONIC INTRATHECAL TREATMENT WITH MORPHINE AND NALOXONE
Autore:
GOUARDERES C; JHAMANDAS K; CRIDLAND R; CROS J; QUIRION R; ZAJAC JM;
Indirizzi:
CNRS,PHARMACOL & TOXICOL FONDAMENTALES LAB,205 ROUTE NARBONNE F-31077TOULOUSE FRANCE QUEENS UNIV,DEPT PHARMACOL KINGSTON K7L 3N6 ONTARIO CANADA MCGILL UNIV,DOUGLAS HOSP RES CTR VERDUN PQ CANADA MCGILL UNIV,DEPT PSYCHIAT VERDUN H4H 1R3 PQ CANADA
Titolo Testata:
Neuroscience
fascicolo: 3, volume: 54, anno: 1993,
pagine: 799 - 807
SICI:
0306-4522(1993)54:3<799:OASRAI>2.0.ZU;2-8
Fonte:
ISI
Lingua:
ENG
Soggetto:
TOLERANT-DEPENDENT RATS; MINI-OSMOTIC PUMPS; BINDING-SITES; AUTORADIOGRAPHIC LOCALIZATION; OPIATE RECEPTORS; BRAIN MEMBRANES; CROSS TOLERANCE; DOWN-REGULATION; UP-REGULATION; MECHANISMS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
C. Gouarderes et al., "OPIOID AND SUBSTANCE-P RECEPTOR ADAPTATIONS IN THE RAT SPINAL-CORD FOLLOWING SUBCHRONIC INTRATHECAL TREATMENT WITH MORPHINE AND NALOXONE", Neuroscience, 54(3), 1993, pp. 799-807

Abstract

The effect of continuous intrathecal infusion with morphine (5 mu/h) or naloxone (2 mug/h) was investigated with regard to analgesia and the apparent density of mu- and delta-opioid and neurokinin-I/substance P receptors in the rat spinal cord. Morphine infusion increased tail-flick and paw-pressure responses until day 4 after the mini-osmotic pump implant. A decline in antinociception, reflecting tolerance to morphine, was then apparent in both tests. Quantitative in vitro receptor autoradiography of [I-125]FK-33824, [I-125][D.Ala2]deltorphin-I and [I-125] Bolton-Hunter substance P binding sites, as ligands of mu, delta and neurokinin-I/substance P receptors, respectively, was performed onlumbosacral spinal cord sections of seven-days tolerant animals. Treatments with morphine and naloxone induced a similar increase (37%) in the number of delta binding sites in the superficial laminae of the dorsal horn. In contrast, the density of mu-opioid receptors was only affected by naloxone (50% increase). Neurokinin-I/substance P binding parameters were not altered by these treatments. Thus, it appears that delta-opioid binding sites may be of special relevance with regard to the development of tolerance to opiates in the spinal cord.

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Documento generato il 18/09/20 alle ore 17:04:45