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Titolo:
BONE-MINERAL CONTENT IN INFANTS AND CHILDREN WITH CHRONIC CHOLESTATICLIVER-DISEASE
Autore:
ARGAO EA; SPECKER BL; HEUBI JE;
Indirizzi:
CHILDRENS HOSP RES FDN,DIV GASTROENTEROL & NUTR,BASIC SCI RES,ROOM 3011,ELLAND & BETHESDA AVE CINCINNATI OH 45229 UNIV CINCINNATI,COLL MED,DEPT PEDIAT CINCINNATI OH 45221
Titolo Testata:
Pediatrics
fascicolo: 6, volume: 91, anno: 1993,
pagine: 1151 - 1154
SICI:
0031-4005(1993)91:6<1151:BCIIAC>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
PRIMARY BILIARY-CIRRHOSIS; VITAMIN-D; ABSORPTION; 25-HYDROXYVITAMIN-D; OSTEOMALACIA; OSTEOPOROSIS; METABOLITES; CHILDHOOD; ATRESIA; PLASMA;
Keywords:
METABOLIC BONE DISEASE; BONE DENSITY; BONE MINERAL CONTENT; CHRONIC CHOLESTATIC DISEASE; VITAMIN-D;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
27
Recensione:
Indirizzi per estratti:
Citazione:
E.A. Argao et al., "BONE-MINERAL CONTENT IN INFANTS AND CHILDREN WITH CHRONIC CHOLESTATICLIVER-DISEASE", Pediatrics, 91(6), 1993, pp. 1151-1154

Abstract

Objective. To assess bone mineral content (BMC) status and serum vitamin D metabolite levels of infants and children with chronic cholestatic liver disease. To determine if severity of bone disease in these patients correlates with serum vitamin D metabolite levels. Methodology. We measured radial BMC with the use of a single-beam photon absorptiometer and serum vitamin D metabolite levels in 56 patients with chronic cholestasis seen at our institution from 1985 through 1991. Patientswere divided into two groups according to age. Results. In group 1 (n= 37; age 2 to 22 months), decreased levels of BMC were seen as earlyas the first few months of life, with sharp decline observed with increasing age (approaching 3 to 5 standard deviations [SD] below the mean, P < .0003). Older patients (group 2, n = 19; age 2 to 20 years) hadBMC values which clustered between 2 and 4 SD below the mean throughout the age range. Although a downward trend also was noted with increasing age, this was not statistically significant. Despite correction for weight-age or height-age, BMC was decreased in most of these patients. No correlation between severity of osteopenia and serum levels of 25(OH)-vitamin D and 1,25(OH)2-vitamin D was observed in either infants or older children. Conclusions. Decreased bone mineralization, as a complication of chronic cholestatic conditions, is a disease process that begins early in infancy, rapidly worsens with increasing age and hepatic dysfunction, and remains relatively stable in children with more stable liver disease.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:23:10