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Titolo:
ENTEROGLUCAGON
Autore:
HOLST JJ;
Indirizzi:
UNIV COPENHAGEN,PANUM INST,DEPT MED PHYSIOL,BLEGDAMSVEJ 3 DK-2200 COPENHAGEN N DENMARK
Titolo Testata:
Annual review of physiology
, volume: 59, anno: 1997,
pagine: 257 - 271
SICI:
0066-4278(1997)59:<257:E>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
GLUCAGON-LIKE PEPTIDE-1; GASTRIC-ACID SECRETION; PANCREATIC BETA-CELLS; HUMAN SMALL-INTESTINE; PIG SMALL-INTESTINE; RAT-BRAIN; INSULINOTROPIC HORMONE; 7-36 AMIDE; PHYSIOLOGICAL INCRETIN; INHIBITORY POLYPEPTIDE;
Keywords:
GLUCAGON-LIKE PEPTIDE-1; GLP-1; GLICENTIN; OXYNTOMODULIN; GLP-2;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
113
Recensione:
Indirizzi per estratti:
Citazione:
J.J. Holst, "ENTEROGLUCAGON", Annual review of physiology, 59, 1997, pp. 257-271

Abstract

The gene encoding proglucagon, the biosynthetic precursor of glucagon, is expressed not only in the pancreatic islets but also in endocrinecells of the gastrointestinal mucosa. The proglucagon (PG)-derived peptides from the gut include glicentin (corresponding to PG 1-69); smaller amounts of oxyntomodulin (PG 33-69) and glicentin-related pancreatic polypeptide (GRPP, PG 1-30); glucagonlike peptide-1 (GLP-1, PG 78-107 amide); intervening peptide-2 (IP-2, PG 111-122 amide); and glucagon-like peptide-2 (GLP-2, PG 126-158). All are secreted into the blood in response to ingestion of carbohydrates and lipids. Only oxyntomodulin and GLP-1 have proven biological activity; oxyntomodulin possibly because it interacts (but with lower potency) with GLP-1 and glucagon receptors. GLP-1 is the most potent insulinotropic hormone known and functions as an incretin hormone. It also inhibits glucagon secretion and, therefore, lowers blood glucose. This effect is preserved in patients with non-insulin-dependent diabetes mellitus, in whom infusions of GLP-1 may completely normalize blood glucose. However, GLP-1 also potently inhibits gastrointestinal secretion and motility, and its physiological functions include mediation of the ''ileal-brake'' effect, i.e.the inhibition of upper gastrointestinal functions elicited by the presence of unabsorbed nutrients in the ileum. As such it may serve to regulate food intake.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 03:59:46