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Titolo:
FUNCTIONAL-HETEROGENEITY OF THE CAUDATE-PUTAMEN AS REVEALED BY C-FOS INDUCTION IN RESPONSE TO D1 RECEPTOR ACTIVATION
Autore:
ARNAULD E; ARSAUT J; DEMOTESMAINARD J;
Indirizzi:
INSERM,U176,RUE CAMILLE ST SAENS F-33077 BORDEAUX FRANCE
Titolo Testata:
Molecular brain research
fascicolo: 4, volume: 18, anno: 1993,
pagine: 339 - 342
SICI:
0169-328X(1993)18:4<339:FOTCAR>2.0.ZU;2-6
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT STRIATAL NEURONS; DOPAMINE-RECEPTORS; GENE; COMPARTMENTS; SUBDIVISIONS;
Keywords:
FOS; STRIATUM; DOPAMINE D1 RECEPTOR; DOPAMINE; HYBRIDIZATION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
16
Recensione:
Indirizzi per estratti:
Citazione:
E. Arnauld et al., "FUNCTIONAL-HETEROGENEITY OF THE CAUDATE-PUTAMEN AS REVEALED BY C-FOS INDUCTION IN RESPONSE TO D1 RECEPTOR ACTIVATION", Molecular brain research, 18(4), 1993, pp. 339-342

Abstract

SKF 38 393, a dopamine receptor agonist which stimulates the D1 receptor, has been shown to activate c-fos to a detectable level in rats only when the striatum has been sensitized by a previous 6-OHDA lesion of the nigrostriatal tract. In the present study, we reexamine the effect of SKF 38 393 by in situ hybridization in non-lesioned mice and show an induction of c-fos mRNA which is restricted to the ventricular edge and to the caudal part of the caudoputamen (CP) even with large doses of SKF 38 393. These results suggest a functional heterogeneity in the CP in response to dopaminergic drugs, which could reflect the anatomical or neurochemical heterogeneity of the striatum itself and its neuroanatomical connections.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 20:08:24