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Titolo:
IONOPHORIC INTERACTION WITH THE MYOCYTE SARCOLEMMA - A NEW INSIGHT INTO THE PATHOPHYSIOLOGY OF DEGENERATIVE MYOCARDIAL-DISEASE
Autore:
WALDENSTROM A; RONQUIST G; FOHLMAN J; GERDIN B; ILBACK NG;
Indirizzi:
UNIV HOSP UPPSALA,DEPT INTERNAL MED,CARDIOL SECT S-75185 UPPSALA SWEDEN UNIV HOSP UPPSALA,DEPT INFECT DIS S-75185 UPPSALA SWEDEN UNIV HOSP UPPSALA,DEPT SURG S-75185 UPPSALA SWEDEN KABI PHARMACIA AB HELSINGBORG SWEDEN
Titolo Testata:
Scandinavian journal of infectious diseases
, , anno: 1993, supplemento:, 88
pagine: 131 - 134
SICI:
0036-5548(1993):<131:IIWTMS>2.0.ZU;2-M
Fonte:
ISI
Lingua:
ENG
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
14
Recensione:
Indirizzi per estratti:
Citazione:
A. Waldenstrom et al., "IONOPHORIC INTERACTION WITH THE MYOCYTE SARCOLEMMA - A NEW INSIGHT INTO THE PATHOPHYSIOLOGY OF DEGENERATIVE MYOCARDIAL-DISEASE", Scandinavian journal of infectious diseases, 1993, pp. 131-134

Abstract

A certain group of compounds often derived from microbes known as ionophores function as ion channels when incorporated in biological membranes. Different ionophores have a relative specificity for certain cations such as Ca2+ or K+. When such compounds are integrated in the cell membrane of a host cell a leakage of the ion in question is induced and the physiologic ion gradient will be dissipated. This will activate ion pumps at the expense of ATP in order to restore the physiologic ion gradient. This effect is seen for a number of different viruses including Coxsackie B3. Based on own experiments we suggest that this ionophoric effect is important in the pathophysiology of myocarditis. Wehave shown that mice with Coxsackie B3 myocarditis have low myocardial ATP and high ADP and AMP levels. This pattern of abnormal energy metabolism is also seen in patients with Syndrome X. It is suggested thatthe ECG and thallium perfusion scintigram suggestive of ischemia in such patients is rather due to the effect of an ionophore leading to anextracellular potassium shift.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 01/12/20 alle ore 09:40:56