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Titolo:
GENOTYPIC AND SEROTYPIC PROFILE IN DIALTED CARDIOMYOPATHY
Autore:
WESSLEN L; WALDENSTROM A; LINDBLOM B; HOYER S; FRIMAN G; FOHLMAN J;
Indirizzi:
UNIV HOSP UPPSALA,DEPT INFECT DIS S-75185 UPPSALA SWEDEN UNIV HOSP UPPSALA,DEPT INFECT DIS S-75185 UPPSALA SWEDEN UNIV HOSP UPPSALA,DEPT INTERNAL MED,CARDIOL SECT S-75185 UPPSALA SWEDEN LINKOPING UNIV HOSP,INST FORENS SEROL S-58185 LINKOPING SWEDEN SONDERBORG HOSP,INST PATHOL DK-6400 SONDERBORG DENMARK
Titolo Testata:
Scandinavian journal of infectious diseases
, , anno: 1993, supplemento:, 88
pagine: 87 - 91
SICI:
0036-5548(1993):<87:GASPID>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
IDIOPATHIC DILATED CARDIOMYOPATHY; VIRUS-SPECIFIC IGM; CARDIAC TRANSPLANTATION; DIABETES-MELLITUS; IMMUNE-RESPONSE; CLASS-II; POLYMORPHISM; INFECTION; SELECTION; CHILDREN;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
L. Wesslen et al., "GENOTYPIC AND SEROTYPIC PROFILE IN DIALTED CARDIOMYOPATHY", Scandinavian journal of infectious diseases, 1993, pp. 87-91

Abstract

Eighteen consecutive patients, admitted with a diagnosis of dilated cardiomyopathy (DCM), to the Cardiology Section, Department of InternalMedicine, University Hospital, Uppsala,Sweden were enrolled into the study.All patients suffered signs of cardiac incompensation of variable duration. Patients were defined by conventional clinical investigations including chest X-ray, ultrasound, g-camera, catheterization and endomyocardial biopsy with histological evaluation by a specially trained pathologist. Angiography was performed to exclude ischemic heart disease. Several patients were diagnosed as having a specific reason forthe cardiac insufficiency, like pheochromocytoma, SLE, ethylism, ischemic heart disease and hypertrophic cardiomyopathy. In this group all 7/7 had negative serology against Coxsackie B viruses. In the other group of idiopathic CM, no other etiology could be found. Serological analysis in this group showed high IgM titres against Coxsackie viruses in 6/8 patients. EDTA-blood was taken for tissue typing using DNA probe hybridisatiom. 6/12 patients had DQB1:4 using the newest nomenclature, vs 17% in the control population. The reversed picture was observedfor DQB1:2, occurring in 1/12 patients, vs 19% in the normal population, thus indicating a protective value of this genotype, which to our knowledge has not been described before. The results indicate a dual dependance of (host) genotype and (virus) serotype according to the Doherty-Zinkernagel hypothesis. Thus, it would also be in agreement with the virus-immune hypothesis suggested more than 20 yews ago to explainthe enigmatic pathogenesis of DCM.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 20:02:48