Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
WORSENING OF POSTURAL TREMOR IN PATIENTS WITH LEVODOPA-INDUCED DYSKINESIA - A QUANTITATIVE-ANALYSIS
Autore:
CALIGIURI MP; LOHR JB;
Indirizzi:
DEPT VET AFFAIRS MED CTR,MOTOR FUNCT LAB,V 116A,3350 LA JOLLA VILLAGEDR SAN DIEGO CA 92161 UNIV CALIF SAN DIEGO,DEPT PSYCHIAT LA JOLLA CA 92093
Titolo Testata:
Clinical neuropharmacology
fascicolo: 3, volume: 16, anno: 1993,
pagine: 244 - 250
SICI:
0362-5664(1993)16:3<244:WOPTIP>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
NEUROLEPTIC-INDUCED PARKINSONISM; TARDIVE-DYSKINESIA; DISEASE; PHARMACOKINETICS; FLUCTUATIONS;
Keywords:
PARKINSONS DISEASE; TREMOR; DYSKINESIA; LEVODOPA;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
M.P. Caligiuri e J.B. Lohr, "WORSENING OF POSTURAL TREMOR IN PATIENTS WITH LEVODOPA-INDUCED DYSKINESIA - A QUANTITATIVE-ANALYSIS", Clinical neuropharmacology, 16(3), 1993, pp. 244-250

Abstract

Some investigators have proposed that Parkinson's disease (PD) patients often exhibit a worsening of tremor before the emergence of levodopa-induced dyskinesia (LDD). It is not clear, however, whether the presence of tremor depends on the severity of dyskinesia, nor is the precise time course of tremor relative to dyskinesia well understood. This report describes an objective study of the relationship between postural tremor and dyskinesia in eight PD patients who showed signs of choreoathetoid hand movements after a single dose of levodopa. Spectral analysis of sustained hand force provided an objective and sensitive method of detecting worsening of tremor in patients with LDD. Severity ofclinical symptoms was highly correlated with severity of dyskinesia. Six of the patients exhibited increased tremor amplitude within 45 minof exposure to levodopa, with two of the six patients experiencing bilateral and four of the six having unilateral worsening of postural tremor. Tremor was more severe on the side with the more severe dyskinesia. These findings provide objective support for the notion that dyskinesia and postural tremor may stem from a common pathophysiologic mechanism.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 04/04/20 alle ore 21:47:12