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Titolo:
THE EMBRYONIC GAMMA-SUBUNIT OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR IS EXPRESSED IN ADULT EXTRAOCULAR-MUSCLE
Autore:
HORTON RM; MANFREDI AA; CONTITRONCONI BM;
Indirizzi:
UNIV MINNESOTA,DEPT BIOCHEM,CBS,174 GORTNER LABS 1479 GORTNER AVE ST PAUL MN 55108 UNIV MINNESOTA,DEPT BIOCHEM,CBS,174 GORTNER LABS 1479 GORTNER AVE ST PAUL MN 55108 UNIV MINNESOTA,DEPT PHARMACOL MINNEAPOLIS MN 55455
Titolo Testata:
Neurology
fascicolo: 5, volume: 43, anno: 1993,
pagine: 983 - 986
SICI:
0028-3878(1993)43:5<983:TEGOTN>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
MYASTHENIA-GRAVIS; CALF-MUSCLE; CDNA; ANTIBODIES; PRECURSOR; CURRENTS; SEQUENCE; CLONING; FIBERS; SNAKE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
R.M. Horton et al., "THE EMBRYONIC GAMMA-SUBUNIT OF THE NICOTINIC ACETYLCHOLINE-RECEPTOR IS EXPRESSED IN ADULT EXTRAOCULAR-MUSCLE", Neurology, 43(5), 1993, pp. 983-986

Abstract

We have PCR-amplified cDNA sequence of the 'embryonic'' gamma subunitof muscle acetylcholine receptor (AChR) from adult bovine extraocularmuscle (EOM). We cloned and sequenced this product and used it to probe Northern blots. We detected the gamma subunit in EOM mRNA, but not in control skeletal muscle. The presence of gamma subunit in EOMs may explain their preferential involvement in myasthenia gravis, where an autoimmune response to the gamma subunit is generally present.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 13/07/20 alle ore 05:04:05