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Titolo:
THE EFFECTS OF TYRAMINE ON SALIVARY FLOW-RATE AND PROTEIN SECRETION BY RAT SUBMANDIBULAR GLANDS
Autore:
OKINA A; HIDAKA S; TASHIRO M; ABE K;
Indirizzi:
FUKUOKA DENT COLL,DEPT ORAL BIOCHEM,700 TA,SAWARA KU FUKUOKA 81401 JAPAN FUKUOKA DENT COLL,DEPT ORAL BIOCHEM,700 TA,SAWARA KU FUKUOKA 81401 JAPAN
Titolo Testata:
Journal of dental research
fascicolo: 5, volume: 72, anno: 1993,
pagine: 897 - 906
SICI:
0022-0345(1993)72:5<897:TEOTOS>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
ALPHA-METHYLNORADRENALINE; PAROTID-GLANDS; ISOPROTERENOL; ELECTROLYTES; CLONIDINE; AGONISTS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
A. Okina et al., "THE EFFECTS OF TYRAMINE ON SALIVARY FLOW-RATE AND PROTEIN SECRETION BY RAT SUBMANDIBULAR GLANDS", Journal of dental research, 72(5), 1993, pp. 897-906

Abstract

The effects of different doses of p-tyramine injected i.v. and i.p. on salivary flow rates and proteins secreted by the submandibular glands of rats were, studied with and without various types of autonomic blockers and two enzyme inhibitors. The salivary flow rates and the amounts of protein secreted progressively increased with increasing doses injected both i.v. and i.p., whereas they were dramatically reduced with all autonomic blockers except the lowest doses of beta-blockers, atropine, and yohimbine. Salivation in response to p-tyramine injected i.v. and i.p. was completely abolished by simultaneous injections of both prazosin and propranolol. The concentration of protein was not dose-dependent and was not reduced by yohimbine and phenoxybenzamine at almost all doses used. However, prazosin significantly increased the protein concentration. Protease activities, were dose-dependent but were significantly reduced with alpha-blockers other than yohimbine, and with most beta-blockers. The proteins secreted in response to p-tyramineat all doses injected i.v. and i.p. were of the alpha-type except with the lowest dose injected i.p. However, the alpha-type was completelyreplaced by the beta-type in the presence of all alpha-blockers except yohimbine, but not with beta-blockers. atropine, or two enzyme inhibitors. Pargyline, a monoamine-oxidase inhibitor, but not disulfiram, adopamine-beta-hydroxylase inhibitor, affected all parameters except the type of protein. Thus, p-tyramine may activate both the alpha1- andbeta1-adrenoceptors in the submandibular glands of rats directly or indirectly.

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Documento generato il 03/12/20 alle ore 15:51:55