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Titolo:
ANTIVIRAL EFFECTS OF DIFFERENT CD4-IMMUNOGLOBULIN CONSTRUCTS AGAINST HIV-1 AND SIV - IMMUNOLOGICAL CHARACTERIZATION, PHARMACOKINETIC DATA AND INVIVO EXPERIMENTS
Autore:
LANGNER KD; NIEDRIG M; FULTZ P; ANDERSON D; REINER G; REPKE H; GELDERBLOM H; SEED B; HILFENHAUS J; ZETTLMEISSL G;
Indirizzi:
UNIV ALABAMA,DEPT MICROBIOL BIRMINGHAM AL 35294 BEHRINGWERKE AG,FORSCHUNGSLAB W-3550 MARBURG GERMANY EMORY UNIV,YERKES REG PRIMATE RES CTR ATLANTA GA 30322 HUMBOLDT UNIV BERLIN,BEREICH MED CHARITE,INST PHARMACOL & TOXICOL O-1040 BERLIN GERMANY ROBERT KOCH INST W-1000 BERLIN 65 GERMANY MASSACHUSETTS GEN HOSP,DEPT MOLEC BIOL BOSTON MA 02114
Titolo Testata:
Archives of virology
fascicolo: 1-2, volume: 130, anno: 1993,
pagine: 157 - 170
SICI:
0304-8608(1993)130:1-2<157:AEODCC>2.0.ZU;2-V
Fonte:
ISI
Lingua:
ENG
Soggetto:
IMMUNODEFICIENCY-VIRUS TYPE-1; RECOMBINANT SOLUBLE CD4; ENVELOPE GLYCOPROTEIN; SYNCYTIUM FORMATION; INFECTED-CELLS; HIGH-AFFINITY; T4 ANTIGEN; BINDING; RECEPTOR; AIDS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
49
Recensione:
Indirizzi per estratti:
Citazione:
K.D. Langner et al., "ANTIVIRAL EFFECTS OF DIFFERENT CD4-IMMUNOGLOBULIN CONSTRUCTS AGAINST HIV-1 AND SIV - IMMUNOLOGICAL CHARACTERIZATION, PHARMACOKINETIC DATA AND INVIVO EXPERIMENTS", Archives of virology, 130(1-2), 1993, pp. 157-170

Abstract

The CD4 cell surface antigen belongs to the immunoglobulin superfamily and is the primary receptor for the human immunodeficiency virus 1 (HIV-1). The high affinity interaction between HIV-1 and CD4 is mediated by the viral envelope glycoprotein gp120. Recombinant soluble CD4 (rsCD4) has been shown in vitro to be an effective inhibitor of HIV-1 and HIV-2 propagation in lymphoid cells. A variety of antibody-like molecules were constructed, consisting of different parts of the extracellular domain of CD4 fused to immunoglobulin constant regions. The fusion proteins were expressed in mammalian cell lines and purified via affinity chromatography. The specificity and anti-viral effects of the different CD4-immunoglobulin constructs against HIV were analysed by different immunological tests, i.e., immunofluorescence, neutralisation and in vitro assays. In pharmacokinetic studies, differences were foundin serum half-life between the four- and two-domain CD4 constructs incynomolgus monkeys and between glycosylated and deglycosylated CD4-Fcconstructs in rabbits. In two in vivo experiments using the four-domain CD4-Fc in SIV-infected macaques, no beneficial effects were observed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 19:05:18