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Titolo:
REDUCTION BY ARACHIDONIC-ACID OF PROSTAGLANDIN-I2-INDUCED CYCLIC-AMP FORMATION - INVOLVEMENT OF PROSTAGLANDIN-E(2) AND PROSTAGLANDIN-F(2-ALPHA)
Autore:
FAILI A; RANDON J; VARGAFTIG BB; HATMI M;
Indirizzi:
INST PASTEUR,INSERM,U285,UNITE PHARMACOL CELLULAIRE,25 RUE DR ROUX F-75724 PARIS 15 FRANCE INST PASTEUR,INSERM,U285,UNITE PHARMACOL CELLULAIRE,25 RUE DR ROUX F-75724 PARIS 15 FRANCE
Titolo Testata:
Biochemical pharmacology
fascicolo: 9, volume: 45, anno: 1993,
pagine: 1815 - 1820
SICI:
0006-2952(1993)45:9<1815:RBAOPC>2.0.ZU;2-3
Fonte:
ISI
Lingua:
ENG
Soggetto:
PLATELET ADENYLATE-CYCLASE; INHIBITION; MEMBRANES; FORSKOLIN; RECEPTORS; AGGREGATION; METABOLISM; ACTIVATION; THROMBIN; DISTINCT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
24
Recensione:
Indirizzi per estratti:
Citazione:
A. Faili et al., "REDUCTION BY ARACHIDONIC-ACID OF PROSTAGLANDIN-I2-INDUCED CYCLIC-AMP FORMATION - INVOLVEMENT OF PROSTAGLANDIN-E(2) AND PROSTAGLANDIN-F(2-ALPHA)", Biochemical pharmacology, 45(9), 1993, pp. 1815-1820

Abstract

Arachidonic acid reverses the increase in cyclic AMP levels of washedhuman platelets exposed to prostaglandin (PG)I2, under conditions where the PGH2 analogue U46619 is ineffective. This effect of arachidonicacid was inhibited by aspirin, a cyclooxygenase inhibitor, but not bythe thromboxane (Tx) synthase inhibitor Ridogrel, which induces, by inhibiting the conversion of PGH2 into TxA2, an overproduction of PGE2,PGD2 and PGF2alpha. Addition of PGE2 or PGF2alpha, which share a receptor with PGI2, to Washed human platelets also induced a decrease in cyclic AMP levels, but PGD2, which interacts with a different receptor,had no effect. Thus neither PGD2, PGG2, PGH2, TxA2 nor TxB2 formed from arachidonic acid via the cyclooxygenase pathway is involved in the decrease in cyclic AMP levels. These findings were confirmed using forskolin, a diterpene from the labdane family, which enhanced the formation of cyclic AMP synergistically with the PGs. Also, arachidonic acid, unlike U46619, is able to reverse the inhibition of platelet aggregation by PGI2 after a lag phase of about 4 min. Our data indicate that arachidonic acid decreased cyclic AMP levels through its cyclooxygenase metabolites PGE2 and PGF2alpha. probably interacting competitively with the receptor of PGI2. In addition, intracellular cyclic AMP levelsand the degree of aggregation of platelets by arachidonic acid seem to be inversely correlated.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/09/20 alle ore 17:27:07