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Titolo:
MULTIPLE 2ND-MESSENGER PATHWAYS MEDIATE AGONIST REGULATION OF MUSCARINIC RECEPTOR MESSENGER-RNA EXPRESSION
Autore:
HABECKER BA; WANG H; NATHANSON NM;
Indirizzi:
UNIV WASHINGTON,SCH MED,DEPT PHARMACOL,SJ-30 SEATTLE WA 98195 UNIV WASHINGTON,SCH MED,DEPT PHARMACOL,SJ-30 SEATTLE WA 98195
Titolo Testata:
Biochemistry
fascicolo: 19, volume: 32, anno: 1993,
pagine: 4986 - 4990
SICI:
0006-2960(1993)32:19<4986:M2PMAR>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
EMBRYONIC CHICK HEART; INDUCED DOWN-REGULATION; ACETYLCHOLINE-RECEPTOR; BETA-2-ADRENERGIC RECEPTOR; PHOSPHOINOSITIDE HYDROLYSIS; ASTROCYTOMA-CELLS; BINDING-PROTEINS; GH3 CELLS; GENE; CAMP;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
B.A. Habecker et al., "MULTIPLE 2ND-MESSENGER PATHWAYS MEDIATE AGONIST REGULATION OF MUSCARINIC RECEPTOR MESSENGER-RNA EXPRESSION", Biochemistry, 32(19), 1993, pp. 4986-4990

Abstract

Muscarinic acetylcholine receptors in the embryonic chicken heart undergo agonist-induced internalization followed by decreases in both receptor number and mRNA expression. Muscarinic agonists cause both inhibition of adenylyl cyclase and activation of phospholipase C in chick heart cells. Treatment of cells with islet activating protein, which blocks coupling of muscarinic receptors to adenylyl cyclase but not phospholipase C, blocks muscarinic receptor-mediated regulation of receptor mRNA levels. Incubation of cells with the partial agonist pilocarpine, which causes inhibition of adenylyl cyclase but not stimulation of phospholipase C, induces less down-regulation of receptor mRNA levels than agonists which regulate both second-messenger systems. Thus, bothsecond-messenger pathways are required for maximal regulation of muscarinic receptor mRNA levels in response to receptor activation. We also demonstrate that the regulation of receptor mRNA by agonist plays animportant role in modulating the rate of recovery of muscarinic acetylcholine receptor number following agonist-induced down-regulation.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 18:31:43