Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
DIFFERENT MECHANISMS ARE INVOLVED IN NEUROPEPTIDE Y-INDUCED PANCREATIC VASOCONSTRICTION AND INHIBITION OF INSULIN-SECRETION
Autore:
SKOGLUND G; GROSS R; AHREN B; LOUBATIERESMARIANI MM;
Indirizzi:
LUND UNIV,MALMO GEN HOSP,DEPT MED S-21401 MALMO SWEDEN LUND UNIV,MALMO GEN HOSP,DEPT MED S-21401 MALMO SWEDEN FAC MED MONTPELLIER,PHARMACOL LAB,CNRS,URA 599 F-34000 MONTPELLIER FRANCE
Titolo Testata:
European journal of pharmacology
fascicolo: 1, volume: 236, anno: 1993,
pagine: 69 - 74
SICI:
0014-2999(1993)236:1<69:DMAIIN>2.0.ZU;2-Y
Fonte:
ISI
Lingua:
ENG
Soggetto:
PIG PANCREAS; RAT PANCREAS; PHENTOLAMINE; NPY; CHANNELS; IMMUNOREACTIVITY; NORADRENALINE; ANTAGONISTS; MESSENGERS; RECEPTORS;
Keywords:
PANCREATIC VESSELS; INSULIN SECRETION; ALPHA-ADRENOCEPTOR ANTAGONISTS; VERAPAMIL; PANCREAS (ISOLATED); CAMP ANALOGS; (RAT);
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
28
Recensione:
Indirizzi per estratti:
Citazione:
G. Skoglund et al., "DIFFERENT MECHANISMS ARE INVOLVED IN NEUROPEPTIDE Y-INDUCED PANCREATIC VASOCONSTRICTION AND INHIBITION OF INSULIN-SECRETION", European journal of pharmacology, 236(1), 1993, pp. 69-74

Abstract

We have studied the mechanisms whereby neuropeptide Y (NPY) inhibits insulin secretion and induces vasoconstriction in the isolated perfused rat pancreas. Neither prazosin (alpha1-adrenoceptor antagonist; 6 muM) nor yohimbine (alpha2-adrenoceptor antagonist; 0.6 muM) affected the effects of neuropeptide Y (1 nM). Also the Ca2+ channel antagonist, verapamil (5 muM), which itself decreased insulin output by 55%, couldnot affect the neuropeptide Y-induced inhibition of insulin secretion. However, verapamil impaired the neuropeptide Y-induced decrease in pancreatic outflow rate. Finally, neuropeptide Y (1 and 10 nM) suppressed the insulin secretion induced by dibutyryl cAMP (100 muM) and the cyclic nucleotide suppressed the neuropeptide Y-induced vasoconstriction. We conclude that the secretory and vascular effects of neuropeptideY are mediated by different processes in the perfused rat pancreas: inhibition of insulin secretion seems mediated by a mechanism distal toand/or different from cAMP generation, whereas vasoconstriction seemsto involve uptake of extracellular Ca2+ and to be sensitive to dibutyryl cAMP. Both effects occur independently of adrenoceptor receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 15:36:33