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Titolo:
PHARMACOKINETICS AND RELATIVE BIOAVAILABILITY OF LOMEFLOXACIN PREPARATIONS IN 10 HEALTHY CHINESE VOLUNTEERS
Autore:
DIAO Y; LU J; LI L; ZHU XD; JI G; WANG EH;
Indirizzi:
NANJING COMMAND INST DRUG CONTROL NANJING 210002 PEOPLES R CHINA
Titolo Testata:
Zhongguo yaoli xuebao
fascicolo: 3, volume: 14, anno: 1993,
pagine: 247 - 249
SICI:
0253-9756(1993)14:3<247:PARBOL>2.0.ZU;2-7
Fonte:
ISI
Lingua:
ENG
Keywords:
LOMEFLOXACIN; TABLETS; CAPSULES; PHARMACOKINETICS; BIOLOGICAL AVAILABILITY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
3
Recensione:
Indirizzi per estratti:
Citazione:
Y. Diao et al., "PHARMACOKINETICS AND RELATIVE BIOAVAILABILITY OF LOMEFLOXACIN PREPARATIONS IN 10 HEALTHY CHINESE VOLUNTEERS", Zhongguo yaoli xuebao, 14(3), 1993, pp. 247-249

Abstract

The pharmacokinetics of lomefloxacin tablet and capsule were determined following a single oral dose of 400 mg given to each of 10 Chinese healthy male volunteers in an open, randomized crossover study. Drug concentrations in plasma were assayed by HPLC method. The peak levels in plasma averaged 6.0+/-1.3 and 5.9+/-1.0 mug . ml-1 at 1.3 +/-0.4 and1.2+/-0.4 h , and the areas under the drug concentration curves were 43+/-15 and 44+/-13 h . mug . ml-1 for lomefloxacin tablet and capsule, respectively. the concentration-time courses after medication conformed to a l-compartment open model with a first order absorption. Pharmacokinetic parameters after tablet did not differ significantly from the corresponding values after capsule. the bioavailability of tablet was comparable to that of capsule.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 14/08/20 alle ore 16:26:29