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Titolo:
PHARMACOKINETICS OF SUSTAINED-RELEASE TABLETS OF METOPROLOL IN CHINESE
Autore:
DIAO Y; LI L;
Indirizzi:
NANJING MIL COMMAND INST DRUG CONTROL NANJING 210002 PEOPLES R CHINA
Titolo Testata:
Zhongguo yaoli xuebao
fascicolo: 3, volume: 14, anno: 1993,
pagine: 232 - 234
SICI:
0253-9756(1993)14:3<232:POSTOM>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Keywords:
METOPROLOL; PHARMACOKINETICS; DELAYED-ACTION PREPARATIONS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
5
Recensione:
Indirizzi per estratti:
Citazione:
Y. Diao e L. Li, "PHARMACOKINETICS OF SUSTAINED-RELEASE TABLETS OF METOPROLOL IN CHINESE", Zhongguo yaoli xuebao, 14(3), 1993, pp. 232-234

Abstract

Single and repeated oral doses pharmacokinetic studies of metoprolol sustained-release tablets (Sino-Swed Pharmaceutical Co Ltd) were performed on 12 Chinese healthy subjects in an open randomized crossover manner, using metoprolol tablets from Sweden Astra Insternational Pharmaceutical Co Ltd as control. Drug concentrations in plasma were assayedby gas chromatography-electron-capture detector method. The percent of drug absorbed in vivo at 1, 2, 4, 6, 8 h correlated well with the amount of drug released in vitro at corresponding time (P> 0. 05). Pharmacokinetic parameters in Chinese after metoprolol tablets were comparable to the reported data in foreigners.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 14:27:43