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Titolo:
URINARY-EXCRETION AND ORIGIN OF 11-DEHYDRO-2,3-DINOR-THROMBOXANE-B2 IN MAN
Autore:
CHIABRANDO C; RIVOLTELLA L; ALBERTI E; BONOLLO M; DJURUP R; FANELLI R;
Indirizzi:
MARIO NEGRI INST PHARMACOL RES,VIA ERITREA 62 I-20157 MILAN ITALY NOVO NORD DK-2880 BAGSVAERD DENMARK
Titolo Testata:
Prostaglandins
fascicolo: 5, volume: 45, anno: 1993,
pagine: 401 - 411
SICI:
0090-6980(1993)45:5<401:UAOO1I>2.0.ZU;2-H
Fonte:
ISI
Lingua:
ENG
Soggetto:
CHROMATOGRAPHY MASS-SPECTROMETRY; LOW-DOSE ASPIRIN; RAT URINE; THROMBOXANE-B2; PROSTACYCLIN; METABOLITES; 2,3-DINOR-THROMBOXANE-B2; IDENTIFICATION; EXTRACTION; PLATELET;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
15
Recensione:
Indirizzi per estratti:
Citazione:
C. Chiabrando et al., "URINARY-EXCRETION AND ORIGIN OF 11-DEHYDRO-2,3-DINOR-THROMBOXANE-B2 IN MAN", Prostaglandins, 45(5), 1993, pp. 401-411

Abstract

The in vivo biosynthesis of thromboxane B2 (TXB2) in man is currentlyevaluated by measuring urinary excretion of its major urinary metabolites, 11-dehydro-TXB2 and 2,3-dinor-TXB2. 11-Dehydro-2,3-dinor-TXB2, another prominent metabolite of exogenous TXB2 in man, has never been measured in human urine. We measured urinary 11-dehydro-2,3-dinor-TXB2 in parallel with 11-dehydro-TXB2 and 2,3-dinor-TXB2 by immunoaffinity extraction/gas chromatography-mass spectrometry in healthy non-smokers(n=12) and age-matched smokers (n=11). In non-smokers, urinary excretion of 11-dehydro-2,3-dinor-TXB2, 11-dehydro-TXB2 and 2,3-dinor-TXB2 was 29.7 +/- 11.1, 53.6 +/- 15.0 and 13.5 +/- 2.8 ng/h (mean +/- SD), respectively. In smokers, only urinary excretion of 2,3-dinor-TXB2 was significantly different (19.7 +/- 6.7 ng/h, p<0.01). Selective inhibition of platelet thromboxane biosynthesis by chronic low-dose aspirin (30 mg/day for 8 days, 4 subjects) comparably reduced platelet-derived metabolites and 11-dehydro-2,3-dinor-TXB2, suggesting that the latter also derives from platelets in healthy subjects.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 06:26:41