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Titolo:
DIFFERENTIAL MODULATION OF MU-OPIOID AND DELTA-OPIOID ANTINOCICEPTIONBY NEUROPEPTIDE FF RECEPTORS IN YOUNG MICE
Autore:
DESPRAT C; ZAJAC JM;
Indirizzi:
CNRS,INST PHARMACOL & BIOL STRUCT,205 ROUTE NARBONNE F-31077 TOULOUSEFRANCE CNRS,INST PHARMACOL & BIOL STRUCT F-31077 TOULOUSE FRANCE
Titolo Testata:
Neuropeptides
fascicolo: 1, volume: 31, anno: 1997,
pagine: 1 - 7
SICI:
0143-4179(1997)31:1<1:DMOMAD>2.0.ZU;2-E
Fonte:
ISI
Lingua:
ENG
Soggetto:
RAT SPINAL-CORD; INDUCED ANALGESIA; NALTRINDOLE; MORPHINE; PEPTIDES; FLFQPQRFAMIDE; F8FAMIDE; ANALOGS; BINDING; PHARMACOLOGY;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
30
Recensione:
Indirizzi per estratti:
Citazione:
C. Desprat e J.M. Zajac, "DIFFERENTIAL MODULATION OF MU-OPIOID AND DELTA-OPIOID ANTINOCICEPTIONBY NEUROPEPTIDE FF RECEPTORS IN YOUNG MICE", Neuropeptides, 31(1), 1997, pp. 1-7

Abstract

The ability of neuropeptide FF (NPFF) to modulate mu- and delta-opioid-induced analgesia by intracerebroventricular administration was compared in adults and 14-day-old mice. In adults, opioid-induced analgesia was predominantly mediated by mu-receptors whereas mu- and delta-receptors were equally involved in pups. An NPFF analog, 1DMe, reduced the analgesic effect of DAGO and [D.Ala(2)]deltorphin-I, mu and delta selective agonists respectively. However, a high dose of 1DMe (22 nmol) increased both morphine and [D.Ala(2)]deltorphin-I-induced analgesia. Dose-response curves for 1DMe in the presence of naltrindole or naltrexone, delta- and mu-opioid selective antagonists respectively, indicate that 1DMe preferentially reversed mu-receptor-mediated but increaseddelta-receptor-mediated analgesia. These findings demonstrate differences in control of mu- and delta-induced analgesia by NPFF receptors.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 10/04/20 alle ore 14:58:30