Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
KINETICS OF CIRCULATING HEMATOPOIETIC PROGENITORS DURING CHEMOTHERAPY-INDUCED MOBILIZATION WITH OR WITHOUT GRANULOCYTE-COLONY-STIMULATING FACTOR
Autore:
LIU KY; AKASHI K; HARADA M; TAKAMATSU Y; NIHO Y;
Indirizzi:
SANSHINKAI HARA HOSP,DEPT HAEMATOL,1-8 TAIHAKU MACHI,HAKATA KU FUKUOKA 812 JAPAN SANSHINKAI HARA HOSP,DEPT HAEMATOL,1-8 TAIHAKU MACHI,HAKATA KU FUKUOKA 812 JAPAN KYUSHU UNIV,FAC MED,DEPT INTERNAL MED 1 FUKUOKA 812 JAPAN
Titolo Testata:
British Journal of Haematology
fascicolo: 1, volume: 84, anno: 1993,
pagine: 31 - 38
SICI:
0007-1048(1993)84:1<31:KOCHPD>2.0.ZU;2-T
Fonte:
ISI
Lingua:
ENG
Soggetto:
STEM-CELL TRANSPLANTATION; HIGH-DOSE THERAPY; AUTOLOGOUS TRANSPLANTATION; RECOMBINANT INTERLEUKIN-6; HEMATOPOIETIC STEM; CFU-GM; BLOOD; LEUKEMIA; MALIGNANCIES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
23
Recensione:
Indirizzi per estratti:
Citazione:
K.Y. Liu et al., "KINETICS OF CIRCULATING HEMATOPOIETIC PROGENITORS DURING CHEMOTHERAPY-INDUCED MOBILIZATION WITH OR WITHOUT GRANULOCYTE-COLONY-STIMULATING FACTOR", British Journal of Haematology, 84(1), 1993, pp. 31-38

Abstract

Kinetics of circulating haematopoietic progenitors was analysed during chemotherapy- or chemotherapy plus granulocyte colony-stimulating factor (G-CSF)-induced mobilization of peripheral blood stem cells. Circulating progenitors including colony-forming unit granulocyte/macrophage (CFU-GM), burst forming-unit erythroid (BFU-E) and multilineage colony forming unit (CFU-Mix) were studied serially on alternate days during a recovery phase from chemotherapy for consolidation of complete remission. In 18 patients with acute leukaemia, 27 courses of consolidation chemotherapy were performed with a combination of an intermediate-dose cytosine arabinoside with etoposide (AraC/Etop) or mitoxantron (Ara-C/Mit). G-CSF (5 mug/kg) was administered during the recovery phase in 6/14 courses with Ara-C/Etop and in 4/13 courses with Ara-C/Mit. G-CSF induced a significant and synchronized increase of circulating CFU-GM, BFU-E and CFU-Mix by more than 4-fold at their peaks. The peak of CFU-GM was significantly correlated with that of both BFU-E and CFU-Mix, irrespective of additional G-CSF mobilization. G-CSF also produced a significant increase of monocytes in a synchronized fashion with an increase of circulating CFU-GM. Interestingly, peripheral blood monocytes spontaneously produced high concentrations of IL-6: a significant correlation was observed between absolute monocyte counts and plasma levels of IL-6 or peak levels of CFU-GM. These observations indicatethat the addition of G-CSF to chemotherapy-induced mobilization can facilitate further expansion of a blood progenitor pool during the haematopoietic recovery, probably through the stimulation of monocytes to proliferate and to induce their monokine production such as IL-6. The data also suggest that absolute monocyte counts may be a useful indicator to predict the peak of circulating progenitors for collecting autologous blood stem cells.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/04/20 alle ore 06:46:06