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Titolo:
SAFETY OF COMBINED HEAT AND MOISTURE EXCHANGER FILTERS IN LONG-TERM MECHANICAL VENTILATION
Autore:
HURNI JM; FEIHL F; LAZOR R; LEUENBERGER P; PERRET C;
Indirizzi:
CHU VAUDOIS,INST PATHOPHYSIOL,BH-19-313 CH-1011 LAUSANNE SWITZERLAND CHU VAUDOIS,INST PHYSIOPATHOL CLIN CH-1011 LAUSANNE SWITZERLAND CHU VAUDOIS,DIV PNEUMOL CH-1011 LAUSANNE SWITZERLAND
Titolo Testata:
Chest
fascicolo: 3, volume: 111, anno: 1997,
pagine: 686 - 691
SICI:
0012-3692(1997)111:3<686:SOCHAM>2.0.ZU;2-U
Fonte:
ISI
Lingua:
ENG
Soggetto:
INTENSIVE-CARE UNIT; VAPORIZING HUMIDIFIERS; CONDENSER HUMIDIFIER; GASES; PERFORMANCE; PATIENT;
Keywords:
AIRWAY HUMIDIFICATION; HEAT AND MOISTURE EXCHANGER; INTENSIVE CARE; MECHANICAL VENTILATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
J.M. Hurni et al., "SAFETY OF COMBINED HEAT AND MOISTURE EXCHANGER FILTERS IN LONG-TERM MECHANICAL VENTILATION", Chest, 111(3), 1997, pp. 686-691

Abstract

Study objective: To evaluate the safety of a combined heat and moisture exchanger filter (HMEF) for the conditioning of inspired gas in long-term mechanical ventilation (MV). Design: Randomized controlled trial. Setting: Medical ICU in a large teaching hospital. Patients: One hundred fifteen consecutive patients who required greater than or equal to 48 h of MV. Interventions: Patients were randomized at intubation time (day 1) to receive inspired gas conditioned either by a water-bathhumidifier heated at 32 degrees C (HWBH) or by an HMEF (Hygroster; DAR; Mirandola, Italy). Measurements and main results: The two study groups were comparable in terms of primary pathologic condition at the time of hospital admission, disease severity as measured by the Simplified Acute Physiology Score, and ICU mortality. They did not differ withrespect to ventilator days per patient (mean +/- SD: HMEF, 7.6 +/- 6.5; HWBH, 7.8 +/- 5.8), incidence of endotracheal tube obstruction (HMEF, 0/59; HWBH, 1/56), and incidence of hypothermic episodes (HMEF, five; HWBH, two). In 41 patients receiving MV for greater than or equal to 5 days, the morphologic integrity of respiratory epithelium was evaluated on day 1 and day 5, using a cytologic examination of tracheal aspirate smears. The state of ciliated epithelium was scored on a scale from 0 (poorest integrity) to 1,200 (maximum integrity), according to a well-described method. In both patient groups, the scores slightly but significantly decreased from day 1 to day 5 (mean +/- SD: HWBH, from 787 +/- 104 to 745 +/- 88; HMEF, from 813 +/- 79 to 739 +/- 62; p < 0.01 for both groups); there were no statistically significant differences between groups. Conclusions: These data indicate acceptable safety of HMEFs of the type used in the present study for long-term mechanical ventilation.

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Documento generato il 10/07/20 alle ore 03:15:33