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Titolo:
LOW-AFFINITY P75 NERVE GROWTH-FACTOR RECEPTOR EXPRESSION IN THE EMBRYONIC MONKEY TELENCEPHALON - TIMING AND LOCALIZATION IN DIVERSE CELLULAR-ELEMENTS
Autore:
MEINECKE DL; RAKIC P;
Indirizzi:
NIMH,DIV NEUROSCI & BEHAV SCI,5600 FISHERS LANE,ROOM 11C-05 ROCKVILLEMD 20857 YALE UNIV,SCH MED,NEUROBIOL SECT NEW HAVEN CT 06510
Titolo Testata:
Neuroscience
fascicolo: 1, volume: 54, anno: 1993,
pagine: 105 - 116
SICI:
0306-4522(1993)54:1<105:LPNGRE>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN BASAL FOREBRAIN; SUBPLATE NEURONS; RAT-BRAIN; CHOLINERGIC SYSTEM; CEREBRAL-CORTEX; MESSENGER-RNA; RHESUS-MONKEY; IMMUNOREACTIVITY; NGF; COLCHICINE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
37
Recensione:
Indirizzi per estratti:
Citazione:
D.L. Meinecke e P. Rakic, "LOW-AFFINITY P75 NERVE GROWTH-FACTOR RECEPTOR EXPRESSION IN THE EMBRYONIC MONKEY TELENCEPHALON - TIMING AND LOCALIZATION IN DIVERSE CELLULAR-ELEMENTS", Neuroscience, 54(1), 1993, pp. 105-116

Abstract

Monoclonal antibodies against the low-affinity (p75) subunit of the human nerve growth factor receptor have been used to determine the temporal appearance of this receptor and to identify the associated cellular elements in the developing occipital cortex of rhesus monkeys. Adult and fetal brains from embryos at embryonic days 45-121 were used. This embryonic time span includes periods of active neurogenesis, cell migration and initial formation of axonal connections in the cerebral cortex. The first immunolabeling in the developing cerebral wall was seen between embryonic days 56 and 64. The labeling was present in the transient subplate neurons, a small number of axonal processes and pericytes associated with blood vessels. By birth, labeled neurons of the subplate zone disappeared, but immunolabeled axonal processes could now be seen in large numbers in the cortex. These findings are consistent with the role of nerve growth factor in the coordination of corticaldifferentiation, but not with the initiation of neuronal proliferation, since the emergence of nerve growth factor receptor-labeled elements in the cortex occurs two to three weeks after the onset of neurogenesis in this species. Further, the diverse cellular elements labeled inthe fetal cerebrum with the antibodies to the low-affinity nerve growth factor receptor suggests that a receptor or receptors associated with growth factor signaling for more than one growth factor family are recognized by these antibodies. Differential timing in the expression of families of growth factor receptors may be one mechanism by which developing neurons in the cerebral cortex could respond to the different signals which guide such processes as synaptogenesis and morphogenesis.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 21/01/20 alle ore 01:02:35