Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
REGIONAL SPECIFICITY OF THE LONG-TERM REGULATION OF TYROSINE-HYDROXYLASE IN SOME CATECHOLAMINERGIC RAT BRAIN-STEM AREAS .1. INFLUENCE OF LONG-TERM HYPOXIA
Autore:
SCHMITT P; PEQUIGNOT J; GARCIA C; PUJOL JF; PEQUIGNOT JM;
Indirizzi:
FAC MED GRANGE BLANCHE,CNRS,URA 1195 04 F-69373 LYON 08 FRANCE FAC MED GRANGE BLANCHE,CNRS,URA 1195 04 F-69373 LYON 08 FRANCE UNIV LYON 1,FAC MED ALEXIS CARREL,NEUROPHARMACOL MOLEC LAB,CNRS,UMR 105 F-69365 LYON 2 FRANCE
Titolo Testata:
Brain research
fascicolo: 1, volume: 611, anno: 1993,
pagine: 53 - 60
SICI:
0006-8993(1993)611:1<53:RSOTLR>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
NUCLEUS TRACTUS SOLITARIUS; LOCUS COERULEUS NEURONS; SPINAL-CORD; EFFERENT PROJECTIONS; NORADRENERGIC NEURONS; CAROTID BARORECEPTORS; SYMPATHETIC-NERVES; MEDULLA-OBLONGATA; BLOOD-PRESSURE; CELL-BODIES;
Keywords:
TYROSINE HYDROXYLASE; CATECHOLAMINERGIC AREA; LONG-TERM HYPOXIA; NOREPINEPHRINE TURNOVER RATE; RAT BRAIN-STEM;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
59
Recensione:
Indirizzi per estratti:
Citazione:
P. Schmitt et al., "REGIONAL SPECIFICITY OF THE LONG-TERM REGULATION OF TYROSINE-HYDROXYLASE IN SOME CATECHOLAMINERGIC RAT BRAIN-STEM AREAS .1. INFLUENCE OF LONG-TERM HYPOXIA", Brain research, 611(1), 1993, pp. 53-60

Abstract

The present study was carried out to investigate the influence of long-term hypoxia on tyrosine hydroxylase (TH) protein quantity in some catecholaminergic rat brainstem areas such as the dorsomedial medulla (DMM), the ventrolateral medulla (VLM) and the locus coeruleus (LC). THprotein quantity was also measured in a dopaminergic structure, the substantia nigra (SN). Male Sprague-Dawley rats were exposed to normobaric hypoxia (10% O2/90% N2) for 3, 7, 14 or 22 days. Controls were kept in normoxia for the same period. This study demonstrates that: (1) 3days of hypoxia produced a 50% and a 26% increase in the quantity of TH protein in the rostral and caudal LC, respectively; (2) 14 days of hypoxia produced a 44% increase of TH protein content exclusively in the caudal part of DMM and a 31% increase in the VLM area; and (3) the stimulus failed to alter the TH protein quantity in the SN. After 14 and 22 days of hypoxia respectively, the TH protein content in the LC and DMM returned to the level of controls. To determine whether the increase in TH protein quantity could be related to a change in norepinephrine (NE) content, the rate constant of disappearance (k) of NE was measured in the catecholaminergic areas of intact or chemodenervated rats submitted to long-term hypoxia. Our results show that hypoxia causes an increase of TH protein quantity within the subpopulations of catecholaminergic areas additionally with an elevation in the NE content. These data suggest a selective response of the TH regulation to long-term hypoxia within the caudal DMM catecholaminergic area which receives chemosensory inputs.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 07/07/20 alle ore 22:17:05