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Titolo:
ACUTE INTERSTITIAL NEPHRITIS WITH SYMMETRICAL ENLARGEMENT OF THE LACRIMAL AND SALIVARY-GLANDS AND SYSTEMIC LYMPHADENOPATHY
Autore:
NAKAMOTO Y; HASHIMOTO K; CHUBACHI A; MIURA AB; WATANUKI T; KONNO A;
Indirizzi:
AKITA UNIV,SCH MED,DEPT INTERNAL MED 3,1-1-1 HONDO AKITA 010 JAPAN AKITA UNIV,SCH MED,DEPT PATHOL 1 AKITA 010 JAPAN AKITA UNIV,SCH MED,DEPT OTORHINOLARYNGOL AKITA 010 JAPAN
Titolo Testata:
American journal of nephrology
fascicolo: 1, volume: 13, anno: 1993,
pagine: 73 - 77
SICI:
0250-8095(1993)13:1<73:AINWSE>2.0.ZU;2-F
Fonte:
ISI
Lingua:
ENG
Soggetto:
GRANULOMAS;
Keywords:
ACUTE INTERSTITIAL NEPHRITIS; ANGIOIMMUNOBLASTIC LYMPHADENOPATHY WITH DYSPROTEINEMIA; GRANULOMA; GIANT CELL OF LANGERHANS TYPE; HYPERIMMUNE STATE;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
10
Recensione:
Indirizzi per estratti:
Citazione:
Y. Nakamoto et al., "ACUTE INTERSTITIAL NEPHRITIS WITH SYMMETRICAL ENLARGEMENT OF THE LACRIMAL AND SALIVARY-GLANDS AND SYSTEMIC LYMPHADENOPATHY", American journal of nephrology, 13(1), 1993, pp. 73-77

Abstract

We describe a 40-year-old man who developed symmetric enlargement of the lacrymal and salivary glands and systemic lymphadenopathy. Laboratory findings included eosinophilia, polyclonal hypergammaglobulinemia,elevated circulating immune complexes, hypocomplementemia, and renal insufficiency. The lymph node pathology was atypical of angioimmunoblastic lymphadenopathy with disproteinemia (AILD), in that it lacked a prominence of arborizing small vessel proliferation. Despite extensive examinations, the cause of the atypical AILD process has not been identified. However, a flow-cytometric analysis of immunophenotypes of lymphoid cells from the lymph node revealed a predominance of activated helper/inducer T cells, indicating a hyperimmune state. Acute interstitial nephritis was secondary to the renal propagation of the atypical AILD process. Thus, atypical AILD can be a new cause of acute interstitial nephritis. A course of combined steroids and immunosuppressive treatment resolved those pathologic disorders for 5 years.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/11/20 alle ore 00:38:39