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Titolo:
EFFECT OF SILYMARIN AND SILYBININ ON OXYGEN RADICALS
Autore:
PASCUAL C; GONZALEZ R; ARMESTO J; MURIEL P;
Indirizzi:
NATL CTR SCI RES,CLIN BIOCHEM LAB,POB 6990 HAVANA CUBA NATL POLYTECH INST,CTR INVEST ESTUDIOS AVANZADOS,DEPT FARMACOL & TOXICOL MEXICO CITY 14 DF MEXICO
Titolo Testata:
Drug development research
fascicolo: 1, volume: 29, anno: 1993,
pagine: 73 - 77
SICI:
0272-4391(1993)29:1<73:EOSASO>2.0.ZU;2-4
Fonte:
ISI
Lingua:
ENG
Soggetto:
LIPID-PEROXIDATION; CHEMI-LUMINESCENCE; DAMAGE; LIVER; PROTECTION; MECHANISM; SILIBININ;
Keywords:
FLAVONOIDS; SILYMARIN; SILYBININ; CATECHIN; OXYGEN RADICALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
19
Recensione:
Indirizzi per estratti:
Citazione:
C. Pascual et al., "EFFECT OF SILYMARIN AND SILYBININ ON OXYGEN RADICALS", Drug development research, 29(1), 1993, pp. 73-77

Abstract

The aim of this work was to study the scavenging action of the flavonoids, silymarin and silybinin (two well known hepatoprotective agents)against different types of oxygen radicals which were generated by specific chemical reactions and detected by luminol-sensitized chemiluminescence. A well known scavenger for each radical was used as control for the paradigm and for comparing its effect with those of the flavonoids. It was found that 0.8 mug/ml of silymarin and 5.5 mg/ml of silybinin produced the same effect as 3.2 ng/ml superoxide dismutase (SOD). An alkoxy radical scavenging effect similar to the one produced by 0.35 ng/ml of vitamin E was caused by 2 mug/ml silymarin and 1.6 ng/ml silybinin. Silybinin was evaluated as a scavenger of hydroxyl radicals by determining the inhibition of the chemiluminescence produced by theFenton reaction with luminol; this was compared with the results obtained from a more conventional method which determines the inhibition of the damage to 2-deoxyribose by the Fenton reaction. In both methods,inhibition was observed at a relatively high concentration of the flavonoid as compared with ethanol. The action of silymarin and silybininas scavengers of oxygen radicals may explain the protective effect ofthese flavonoids in certain forms of liver disease where free radicals are involved. However, other properties of these compounds cannot bediscarded for their hepatoprotective actions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 02:27:49