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Titolo:
NITRIC OXIDE-RELATED VASODILATOR RESPONSES TO PARASYMPATHETIC STIMULATION OF THE SUBMANDIBULAR-GLAND IN THE CAT
Autore:
EDWARDS AV; GARRETT JR;
Indirizzi:
UNIV CAMBRIDGE,PHYSIOL LAB CAMBRIDGE CB2 3EJ ENGLAND KINGS COLL,SCH MED & DENT,DEPT ORAL PATHOL LONDON SE5 9NU ENGLAND
Titolo Testata:
Journal of physiology
, volume: 464, anno: 1993,
pagine: 379 - 392
SICI:
0022-3751(1993)464:<379:NOVRTP>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASOACTIVE INTESTINAL POLYPEPTIDE; ENDOTHELIUM-DEPENDENT RELAXATION; GUINEA-PIG TRACHEA; SALIVARY-GLANDS; PULMONARY-ARTERY; PEPTIDE; ACETYLCHOLINE; SECRETION; VIP; INVIVO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
A.V. Edwards e J.R. Garrett, "NITRIC OXIDE-RELATED VASODILATOR RESPONSES TO PARASYMPATHETIC STIMULATION OF THE SUBMANDIBULAR-GLAND IN THE CAT", Journal of physiology, 464, 1993, pp. 379-392

Abstract

1. The extent to which parasympathetic vasodilator responses, in the submandibular gland of the cat, depend upon release of nitric oxide related (NO(x)) or endothelium-derived relaxing factor (EDRF) within thegland has been investigated in anaesthetized cats given N(omega)-nitro-L-arginine methyl ester (L-NAME) which specifically blocks the synthesis of EDRF from arginine. 2. Close intra-arterial infusions Of L-NAME (greater-than-or-equal-to 100 mg kg-1) produced a steady and significant rise in mean aortic pressure together with a steady increase in basal submandibular vascular resistance over the next 20-30 min, which persisted thereafter. 3. In cats pretreated with propranolol, to blockbeta-adrenoceptor-mediated vasodilatation, salivation and vasodilatation in response to stimulation of the chorda-lingual nerve were reduced but not abolished by L-NAME (greater-than-or-equal-to 100 mg kg-1, I. A.). Subsequent administration of atropine (greater-than-or-equal-to 1 mg kg-1 i.v.) completely suppressed the secretory response and virtually eliminated the vascular response. 4. In cats pretreated with atropine (greater-than-or-equal-to 1.0 mg kg-1 i.v.) administration of L-NAME (greater-than-or-equal-to 100 mg kg-1 I.A.) effectively suppressedthe vasodilator response to chorda-lingual stimulation at 2 Hz continuously, or at 20 Hz for 1 s at 10 s intervals. 5. Administration Of L-NAME (greater-than-or-equal-to 100 mg kg-1 I.A.) effectively suppressed the submandibular vasodilator response to infusions of VIP (10 and 20 ng I.A.) and significantly reduced, but did not abolish that to acetylcholine (100 ng min-1 I.A.). 6. These results provide further support for the view that both acetylcholine and vasoactive intestinal polypeptide-like immunoreactivity (VIP) are released from the postganglionic parasympathetic nerve terminals and produce effects on the blood vessels in submandibular glands of the cat. They also provide evidence for a direct vascular action of acetylcholine, independent of NO(x), butVIP appears to act indirectly via NO(x) formation.

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Documento generato il 29/09/20 alle ore 14:07:08