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Titolo:
CENTRAL AND PERIPHERAL ADMINISTRATION OF ATRIOPEPTIN IS ANXIOLYTIC INRATS
Autore:
STROHLE A; JAHN H; MONTKOWSKI A; LIEBSCH G; BOLL E; LANDGRAF R; HOLSBOER F; WIEDEMANN K;
Indirizzi:
MAX PLANCK INST PSYCHIAT,INST CLIN,KRAEPELINSTR 2-10 D-80804 MUNICH GERMANY
Titolo Testata:
Neuroendocrinology
fascicolo: 3, volume: 65, anno: 1997,
pagine: 210 - 215
SICI:
0028-3835(1997)65:3<210:CAPAOA>2.0.ZU;2-R
Fonte:
ISI
Lingua:
ENG
Soggetto:
ATRIAL-NATRIURETIC-FACTOR; CORTICOTROPIN-RELEASING FACTOR; BLOOD-BRAIN-BARRIER; RECEPTOR ANTISENSE OLIGODEOXYNUCLEOTIDE; ANTERIOR-PITUITARY-CELLS; ANXIETY-RELATED BEHAVIOR; SOCIALLY DEFEATED RATS; HYPOTHALAMUS INVITRO; STIMULATED SECRETION; VASOPRESSIN RELEASE;
Keywords:
ATRIAL NATRIURETIC PEPTIDE; ANXIETY; BEHAVIOR; ADRENAL STEROIDS; AMYGDALA;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
57
Recensione:
Indirizzi per estratti:
Citazione:
A. Strohle et al., "CENTRAL AND PERIPHERAL ADMINISTRATION OF ATRIOPEPTIN IS ANXIOLYTIC INRATS", Neuroendocrinology, 65(3), 1997, pp. 210-215

Abstract

The effects of the central and peripheral administration of atriopeptin II, a 23-amino acid residue peptide of atrial natriuretic peptide (Ser(103)-Arg(125)) on anxiety-related behavior and on locomotor activity, was studied in male Wistar rats. Their behavior on the elevated plus-maze after social defeat stress indicated that intracerebroventricular (2.5 and 5 mu g) and intraperitoneal (50 mu g) administration of atriopeptin ZI produced anxiolysis. A low dose of 0.25 mu g atriopeptinII administered bilaterally into the central nucleus of the amygdala was also found to be anxiolytic. Because intracerebroventricular administration of 5 mu g atriopeptin II did not affect locomotor activity in the open-field test, the possibility that the anxiolytic effect was secondary to sedation could be ruled out. The anxiolytic effects observed after central and peripheral administration support the idea that atrial natriuretic peptide, which is increased in panic-anxiety, may be involved in the tapering of anxiety-related behavior.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 08:38:23