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Titolo:
PHARMACOLOGICAL AND IMMUNOHISTOCHEMICAL EVIDENCE FOR SEROTONERGIC MODULATION OF CHOLINERGIC NUCLEUS BASALIS NEURONS
Autore:
KHATEB A; FORT P; ALONSO A; JONES BE; MUHLETHALER M;
Indirizzi:
UNIV GENEVA,MED CTR,DEPT PHYSIOL,1 RUE MICHEL SERVET CH-1211 GENEVA 4SWITZERLAND UNIV GENEVA,MED CTR,DEPT PHYSIOL,1 RUE MICHEL SERVET CH-1211 GENEVA 4SWITZERLAND MCGILL UNIV,MONTREAL NEUROL INST,DEPT NEUROL & NEUROSURG MONTREAL H3A2B4 QUEBEC CANADA
Titolo Testata:
European journal of neuroscience
fascicolo: 5, volume: 5, anno: 1993,
pagine: 541 - 547
SICI:
0953-816X(1993)5:5<541:PAIEFS>2.0.ZU;2-A
Fonte:
ISI
Lingua:
ENG
Soggetto:
LOCUS COERULEUS NEURONS; SLEEP-WAKEFULNESS CYCLE; BRAIN-STEM AFFERENTS; ASCENDING PROJECTIONS; AUTORADIOGRAPHIC ANALYSIS; SUBSTANTIA INNOMINATA; RETICULAR-FORMATION; AXONAL-TRANSPORT; UNIT-ACTIVITY; DORSAL RAPHE;
Keywords:
LOW THRESHOLD SPIKE; 5-HT(1A) RECEPTOR; SUBSTANTIA INNOMINATA; SLEEP; GUINEA-PIG;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
54
Recensione:
Indirizzi per estratti:
Citazione:
A. Khateb et al., "PHARMACOLOGICAL AND IMMUNOHISTOCHEMICAL EVIDENCE FOR SEROTONERGIC MODULATION OF CHOLINERGIC NUCLEUS BASALIS NEURONS", European journal of neuroscience, 5(5), 1993, pp. 541-547

Abstract

Identified electrophysiologically by low threshold bursts and transient outward rectification, cholinergic nucleus basalis neurons were recorded and labelled intracellularly in guinea-pig basal forebrain slices. By means of a triple labelling immunofluorescent technique, serotonin-immunoreactive fibres were visualized in close proximity to the soma and dendrites of the biocytin-labelled, choline acetyl transferase (ChAT)-immunoreactive cells. By bath application, 5-hydroxytryptamine (5-HT) produced a direct hyperpolarization of the identified cells which was mimicked by 5-HT1A receptor agonists, suggesting that it may inhibit the tonic firing but also modulate the low threshold bursting of the cholinergic nucleus basalis neurons.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/07/20 alle ore 06:40:09