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Titolo:
EFFECT OF CAROTID-SINUS STIMULATION ON RESISTANCE AND CRITICAL CLOSING PRESSURE OF THE CANINE HINDLIMB
Autore:
SHRIER I; HUSSAIN SNA; MAGDER S;
Indirizzi:
ROYAL VICTORIA HOSP,DIV CRIT CARE MED L305,687 PINE AVE W MONTREAL H3A 1A1 QUEBEC CANADA
Titolo Testata:
The American journal of physiology
fascicolo: 5, volume: 264, anno: 1993,
parte:, 2
pagine: 1560 - 1566
SICI:
0002-9513(1993)264:5<1560:EOCSOR>2.0.ZU;2-Q
Fonte:
ISI
Lingua:
ENG
Soggetto:
ZERO-FLOW PRESSURE; CAPACITANCE;
Keywords:
PRESSURE-FLOW RELATIONSHIP; STARLING RESISTOR; ARTERIAL COMPLIANCE; VENOUS RESISTANCE;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
22
Recensione:
Indirizzi per estratti:
Citazione:
I. Shrier et al., "EFFECT OF CAROTID-SINUS STIMULATION ON RESISTANCE AND CRITICAL CLOSING PRESSURE OF THE CANINE HINDLIMB", The American journal of physiology, 264(5), 1993, pp. 1560-1566

Abstract

Sympathetically mediated changes in blood pressure are thought to occur through changes in arterial resistance (R(a)). To test whether the critical closing pressure (P(crit)) could also play a role, we pump-perfused the vascularly isolated canine hindlimb at constant flow. Carotid sinuses were isolated and both vagus nerves cut. Carotid sinus (P(car)), arterial, perfusion (P(per)), and venous (P(v)) pressures and flow to the hindlimb (Q, electromagnetic flow probe) were measured. By decreasing pump flow to zero over time periods of 1-10 s and measuring the pressure at zero-flow, it was possible to estimate arterial compliance and P(crit). R(a) was calculated as (P(per) - P(crit))/Q. Venous resistance was calculated as (P(el) - P(v))/Q, where P(el) is the pressure in the compliant region obtained by the double-occlusion technique. Raising P(car) from 115 +/- 7 to 203 +/- 10 mmHg (n = 6) decreased P(crit) from 49.7 +/- 4.3 to 25.9 +/- 2.6 mmHg and R. from 10.7 +/- 1.2 to 6.8 +/- 0.9 mmHg. min . 100 g-1 . ml-1 (P < 0.05). Lowering P(car) from 119 +/- 6 to 71 +/- 6 mmHg (n = 6) increased P(crit) from 37.0 /- 3.3 to 61.0 +/- 8.5 mmHg and R(a) from 10.0 +/- 1.6 to 14.0 +/- 2.4 mmHg . min . 100 g . ml-1 (P < 0.05). Arterial compliance increased when P(car) was raised (P < 0.05) and decreased when P(car) was decreased (P < 0.1). Venous resistance did not change when P(car) was altered. In conclusion, changes in carotid sinus stimulation alters blood flow to the hindlimb through changes in both P(car) and R(a).

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 28/11/20 alle ore 12:53:53