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Titolo:
ADENOSINE REGULATES CORONARY BLOOD-FLOW DURING INCREASED WORK AND DECREASED SUPPLY
Autore:
MARTIN SE; LENHARD SD; SCHMARKEY LS; OFFENBACHER S; ODLE B;
Indirizzi:
2744 MARYLAND AVE BALTIMORE MD 21218 EMORY UNIV,CRAWFORD LONG HOSP,CARLYLE FRASER HEART CTR,DEPT MED CARDIOL ATLANTA GA 30365 EMORY UNIV,CRAWFORD LONG HOSP,CARLYLE FRASER HEART CTR,DEPT PHYSIOL ATLANTA GA 30365 EMORY UNIV,SCH MED,SCH POSTGRAD DENT ATLANTA GA 30365
Titolo Testata:
The American journal of physiology
fascicolo: 5, volume: 264, anno: 1993,
parte:, 2
pagine: 1438 - 1446
SICI:
0002-9513(1993)264:5<1438:ARCBDI>2.0.ZU;2-1
Fonte:
ISI
Lingua:
ENG
Soggetto:
FUNCTIONAL HYPEREMIA; MYOCARDIAL ADENOSINE; CONSTRICTION; HEART; AMINOPHYLLINE; THEOPHYLLINE; STIMULATION; VASOPRESSIN; BLOCKADE; RELEASE;
Keywords:
DOBUTAMINE; ARGININE VASOPRESSIN; DOGS; 8-P-SULFOPHENYLTHEOPHYLLINE; METABOLIC REGULATION OF CORONARY BLOOD FLOW; PROSTACYCLIN; VASODILATORS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
34
Recensione:
Indirizzi per estratti:
Citazione:
S.E. Martin et al., "ADENOSINE REGULATES CORONARY BLOOD-FLOW DURING INCREASED WORK AND DECREASED SUPPLY", The American journal of physiology, 264(5), 1993, pp. 1438-1446

Abstract

Adenosine may mediate coronary vasodilation during work-related hyperemia and during ischemia. We tested whether adenosine blockade with 8-p-sulfophenyltheophylline (PSPT) prevented dobutamine-induced hyperemia or magnified the reductions in flow due to vasopressin. Control (n =8) and test (n = 7) dogs received paired infusions of dobutamine (70 mug/min iv for 5 min). Test dogs received PSPT (10 mg/kg iv) between doses. In both groups, paired infusions elicited comparable increases in oxygen consumption. However, in test dogs, the hyperemia was reducedsignificantly. Thus adenosine mediates the hyperemia of dobutamine. Separately, control dogs (n = 9) received vasopressin (0.6 mug ic over 5 min); test dogs (n = 7) received PSPT before vasopressin. Vasopressin maximally increased coronary resistance by 3 min; effects were gone by 10 min. With PSPT, coronary resistance was increased further and remained high beyond 10 min. Thus adenosine-mediated vasodilation moderates the severity and duration of ischemia. These results indicate the importance of adenosine in mediating coronary flow during increased demand and reduced supply.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/01/20 alle ore 09:23:39