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Titolo:
PRESENT STATUS AND FUTURE-PROSPECTS FOR HIV THERAPIES
Autore:
JOHNSTON MI; HOTH DF;
Indirizzi:
NIAID,DIV AIDS,BASIC RES & DEV PROGRAM BETHESDA MD 20892
Titolo Testata:
Science
fascicolo: 5112, volume: 260, anno: 1993,
pagine: 1286 - 1293
SICI:
0036-8075(1993)260:5112<1286:PSAFFH>2.0.ZU;2-B
Fonte:
ISI
Lingua:
ENG
Soggetto:
HUMAN-IMMUNODEFICIENCY-VIRUS; REVERSE-TRANSCRIPTASE INHIBITORS; AIDS-RELATED COMPLEX; PLACEBO-CONTROLLED TRIAL; RECOMBINANT SOLUBLE CD4; CHRONICALLY INFECTED-CELLS; DEFICIENCY SYNDROME AIDS; BLOOD MONONUCLEAR-CELLS; MURINE LEUKEMIA-VIRUS; REV TRANS-ACTIVATOR;
Tipo documento:
Review
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
258
Recensione:
Indirizzi per estratti:
Citazione:
M.I. Johnston e D.F. Hoth, "PRESENT STATUS AND FUTURE-PROSPECTS FOR HIV THERAPIES", Science, 260(5112), 1993, pp. 1286-1293

Abstract

Since the discovery of human immunodeficiency virus (HIV) in 1983, significant progress has been made toward the discovery, development, and licensing of anti-HIV drugs. In vitro screens against whole virus are now being complemented by screens against specific viral targets, resulting in the development of clinical candidates acting at several critical stages of the viral life cycle. Despite these advances, clinical therapy remains largely palliative. In addition, it has recently been recognized that HIV resistance to most drugs may pose even greater obstacles. Moreover, emerging data on immunopathogenesis raise the possibility that even if virus was eliminated from an infected individual,the patient's immune system might not be capable of restoration to normal function. In the face of such obstacles, deeper insights into thepathogenic mechanisms of disease, aggressive exploitation of those mechanisms for therapeutic gain, and continued commitment of both publicand private sectors to support and collaborate in this research are needed.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 22/09/20 alle ore 08:02:25