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Titolo:
REDUCED SECRETION OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA BYNEONATAL MONOCYTES
Autore:
PETERS AMJ; BERTRAM P; GAHR M; SPEER CP;
Indirizzi:
UNIV GOTTINGEN,DEPT PEDIAT,ROBERT KOCH STR 40 W-3400 GOTTINGEN GERMANY
Titolo Testata:
Biology of the neonate
fascicolo: 3, volume: 63, anno: 1993,
pagine: 157 - 162
SICI:
0006-3126(1993)63:3<157:RSOIAT>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
CORD BLOOD MONOCYTES; FACTOR CACHECTIN; MACROPHAGES; ACTIVATION; NEWBORNS; CELLS; IL-1;
Keywords:
INTERLEUKIN-1; TUMOR NECROSIS FACTOR-ALPHA; NEONATES; MONOCYTES;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
20
Recensione:
Indirizzi per estratti:
Citazione:
A.M.J. Peters et al., "REDUCED SECRETION OF INTERLEUKIN-1 AND TUMOR-NECROSIS-FACTOR-ALPHA BYNEONATAL MONOCYTES", Biology of the neonate, 63(3), 1993, pp. 157-162

Abstract

Monocytes were isolated from peripheral blood of preterm and term newborn infants and adult controls, and their capacity to secrete the inflammatory mediators interleukin-1 (IL-1) and tumor necrosis factor-alpha (TNF-alpha) was investigated. Lipopolysaccharide (LPS)-stimulated neonatal monocytes secreted significantly less IL-I (median: 1.1 U/ml) than monocytes from adult controls (median: 7.3 U/ml). In addition TNF-alpha production by LPS-stimulated neonatal monocytes (median: 610 pg/ml) was significantly lower when compared with controls (median: 2230pg/ml). Our data provide evidence that neonatal monocytes have a profoundly impaired cytokine secretion.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 05/12/20 alle ore 04:14:27