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Titolo:
POTENTIATION OF DEVELOPING NEUROMUSCULAR SYNAPSES BY THE NEUROTROPHINS NT-3 AND BDNF
Autore:
LOHOF AM; IP NY; POO MM;
Indirizzi:
COLUMBIA UNIV,DEPT BIOL SCI NEW YORK NY 10027 COLUMBIA UNIV,DEPT BIOL SCI NEW YORK NY 10027 REGENERON PHARMACEUT INC TARRYTOWN NY 10591
Titolo Testata:
Nature
fascicolo: 6427, volume: 363, anno: 1993,
pagine: 350 - 353
SICI:
0028-0836(1993)363:6427<350:PODNSB>2.0.ZU;2-L
Fonte:
ISI
Lingua:
ENG
Soggetto:
NERVE GROWTH-FACTOR; NEURONS; EXPRESSION; NGF; RECEPTOR; CULTURE; INDUCTION; PATTERNS; INVITRO;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
35
Recensione:
Indirizzi per estratti:
Citazione:
A.M. Lohof et al., "POTENTIATION OF DEVELOPING NEUROMUSCULAR SYNAPSES BY THE NEUROTROPHINS NT-3 AND BDNF", Nature, 363(6427), 1993, pp. 350-353

Abstract

THE neurotrophins are a family of neurotrophic factors that promote survival and differentiation of various neuronal populations1,2. Although the long-term effects of neurotrophins on neuronal survival and differentiation have been intensively studied, nothing is known about their effects on synaptic function. Here we report that acute exposure toneurotrophin-3 (NT-3)3,4 or brain-derived neurotrophic factor (BDNF)5, but not nerve growth factor (NGF)6, rapidly potentiates the spontaneous and impulse-evoked synaptic activity of developing neuromuscular synapses in culture. The effect appears to be presynaptic in origin andto be mediated by the Trk family of receptor tyrosine kinases7. Theseresults provide evidence for the regulation of the function of developing synapses by neurotrophins.

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Documento generato il 01/04/20 alle ore 17:41:15