Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
INDUCTION OF LTP IN THE HIPPOCAMPUS NEEDS SYNAPTIC ACTIVATION OF GLUTAMATE METABOTROPIC RECEPTORS
Autore:
BASHIR ZI; BORTOLOTTO ZA; DAVIES CH; BERRETTA N; IRVING AJ; SEAL AJ; HENLEY JM; JANE DE; WATKINS JC; COLLINGRIDGE GL;
Indirizzi:
UNIV BIRMINGHAM,SCH MED,DEPT PHARMACOL BIRMINGHAM B15 2TT W MIDLANDS ENGLAND UNIV BRISTOL,SCH MED SCI,DEPT PHARMACOL BRISTOL BS8 1TD AVON ENGLAND
Titolo Testata:
Nature
fascicolo: 6427, volume: 363, anno: 1993,
pagine: 347 - 350
SICI:
0028-0836(1993)363:6427<347:IOLITH>2.0.ZU;2-C
Fonte:
ISI
Lingua:
ENG
Soggetto:
LONG-TERM POTENTIATION; PROTEIN KINASE-C; RAT HIPPOCAMPUS; BLOCKS INDUCTION; STRIATAL NEURONS; AREA CA1; ACID; TRANSMISSION; MAINTENANCE; STIMULATION;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
Z.I. Bashir et al., "INDUCTION OF LTP IN THE HIPPOCAMPUS NEEDS SYNAPTIC ACTIVATION OF GLUTAMATE METABOTROPIC RECEPTORS", Nature, 363(6427), 1993, pp. 347-350

Abstract

UNDERSTANDING the mechanisms of long-term potentiation (LTP) should provide insights into the molecular basis of learning and memory in vertebrates. Ionotropic glutamate receptors play a central role in LTP; AMPA ha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate) receptors and NMDA (N-methyl-D-aspartate) receptors mediate synaptic responses that are enhanced in LTP and, in addition, NMDA receptors are necessary for the induction of LTP in most pathways1. There is also circumstantial evidence that metabotropic glutamate receptors (mGluRs) may be involvedin LTP because the specific mGluR agonist aminocyclopentane dicarboxylate can augment tetanus-induced LTP2 and, under certain circumstances, can itself induce a slow-onset potentiation3,4. But the absence of any effective mGluR antagonist has prevented the determination of whether mGluRs are involved in the induction of tetanus-induced LTP. We report here that (RS)-alpha-methyl-4-carboxyphenylglycine is a specific mGluR antagonist in the hippocampus and have used this compound to examine the nature of the involvement of mGluRs in LTP. We show that synaptic activation of mGluRs is necessary for the induction of both NMDA receptor-dependent and NMDA receptor-independent forms of LTP in the hippocampus.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 20/09/20 alle ore 07:03:23