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Titolo:
SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY WITH TC-99M-EXAMETAZIME INUNMEDICATED SCHIZOPHRENIC-PATIENTS
Autore:
EBMEIER KP; BLACKWOOD DHR; MURRAY C; SOUZA V; WALKER M; DOUGALL N; MOFFOOT APR; OCARROLL RE; GOODWIN GM;
Indirizzi:
ROYAL EDINBURGH & ASSOCIATED HOSP,MRC,BRAIN METAB UNIT,MORNINGSIDE PKEDINBURGH EH10 5HF SCOTLAND UNIV EDINBURGH,MRC,BRAIN METAB UNIT EDINBURGH EH8 9YL MIDLOTHIAN SCOTLAND UNIV EDINBURGH,DEPT PSYCHIAT EDINBURGH EH8 9YL MIDLOTHIAN SCOTLAND
Titolo Testata:
Biological psychiatry
fascicolo: 7, volume: 33, anno: 1993,
pagine: 487 - 495
SICI:
0006-3223(1993)33:7<487:SECWTI>2.0.ZU;2-#
Fonte:
ISI
Lingua:
ENG
Soggetto:
CEREBRAL BLOOD-FLOW; DORSOLATERAL PREFRONTAL CORTEX; BRAIN GLUCOSE-METABOLISM; PSYCHIATRIC-DISORDERS; MAGNETIC-RESONANCE; PET; SPECT; ABNORMALITIES; PERFORMANCE; DYSFUNCTION;
Keywords:
SINGLE-PHOTON EMISSION TOMOGRAPHY; SCHIZOPHRENIA; CEREBRAL BLOOD FLOW;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
52
Recensione:
Indirizzi per estratti:
Citazione:
K.P. Ebmeier et al., "SINGLE-PHOTON EMISSION COMPUTED-TOMOGRAPHY WITH TC-99M-EXAMETAZIME INUNMEDICATED SCHIZOPHRENIC-PATIENTS", Biological psychiatry, 33(7), 1993, pp. 487-495

Abstract

We examined 20 actively psychotic unmedicated schizophrenic patients and 20 matched control subjects by using single-photon emission, computed tomography (SPECT) with technetium-99m-exametazime. Patients showed a hyperfrontal pattern of tracer uptake with significant relative increases in superior prefrontal cortex. This abnormality was less pronounced in patients with higher symptom scores for psychomotor poverty. In addition, patients showed associations between certain schizophrenic syndrome scores, such as psychomotor poverty, disorganization, and reality distortion, and tracer uptake to a number of cortical and subcortical brain regions. This syndrome-related pattern of tracer uptake was, at least in part, consistent with similar associations previously reported in chronically medicated schizophrenic patients. SPECT therefore provides a readily available method to examine the relationship between symptom pattern and regional brain metabolism in psychotic patients. Any observed patterns of association will depend on the current mental and medication status of the patients examined.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 25/02/20 alle ore 08:13:17