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Titolo:
CRITERIA FOR RATIONALLY EVALUATING ANIMAL-MODELS OF POSTTRAUMATIC-STRESS-DISORDER
Autore:
YEHUDA R; ANTELMAN SM;
Indirizzi:
VET ADM MED CTR,DEPT PSYCHIAT,POSTTRAUMAT STRESS PROGRAM,130 W KINGSBRIDGE RD BRONX NY 10468 CUNY MT SINAI SCH MED,DEPT PSYCHIAT NEW YORK NY 10029 UNIV PITTSBURGH,WESTERN PSYCHIAT INST & CLIN,SCH MED,DEPT PSYCHIAT PITTSBURGH PA 15213 UNIV PITTSBURGH,SCH MED,PITTSBURGH CANC INST PITTSBURGH PA 15261
Titolo Testata:
Biological psychiatry
fascicolo: 7, volume: 33, anno: 1993,
pagine: 479 - 486
SICI:
0006-3223(1993)33:7<479:CFREAO>2.0.ZU;2-G
Fonte:
ISI
Lingua:
ENG
Soggetto:
POST-TRAUMATIC STRESS; TIME-DEPENDENT SENSITIZATION; INESCAPABLE SHOCK; DEPRESSION; EXPOSURE; NOREPINEPHRINE; VALIDATION; DEFICITS; DIAZEPAM; DOPAMINE;
Keywords:
STRESS; ANIMAL MODELS; POSTTRAUMATIC STRESS DISORDER; INESCAPABLE SHOCK; LEARNED HELPLESSNESS; TIME-DEPENDENT SENSITIZATION;
Tipo documento:
Note
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Citazioni:
53
Recensione:
Indirizzi per estratti:
Citazione:
R. Yehuda e S.M. Antelman, "CRITERIA FOR RATIONALLY EVALUATING ANIMAL-MODELS OF POSTTRAUMATIC-STRESS-DISORDER", Biological psychiatry, 33(7), 1993, pp. 479-486

Abstract

Animal models of stress have the potential to provide information about the course and etiology of posttraumatic stress disorder (PTSD). Todate, however, there have been no systematic approaches for evaluating the relevance of animal models of stress to PTSD. It has been established in the animal literature that different types of stress paradigms lead to different biobehavioral consequences and that many differentfactors contribute to differential responsivity to stress. It becomesimportant therefore to differentiate between factors that are essential to the induction of PTSD-like symptoms and those that influence their manifestations. In the present commentary, we present five criteriathat must be fulfilled by animal models of stress for them to be useful to understanding the induction of PTSD. We then evaluate two potential animal models of stress-inescapable shock-learned helplessness andtime-dependent sensitization-to illustrate how to more successfully pair animal models of stress with the specific clinical syndrome of PTSD.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 27/01/21 alle ore 01:16:57