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Titolo:
REINFORCING SUBJECTIVE EFFECTS OF (+ -) 3,4-METHYLENEDIOXYMETHAMPHETAMINE (ECSTASY) MAY BE SEPARABLE FROM ITS NEUROTOXIC ACTIONS - CLINICAL-EVIDENCE/
Autore:
MCCANN UD; RICAURTE GA;
Indirizzi:
NIMH,BIOL PSYCHIAT BRANCH,ANXIETY & AFFECT DISORDERS SECT,BLDG 10 BETHESDA MD 20892 JOHNS HOPKINS UNIV,SCH MED,FRANCIS SCOTT KEY MED CTR,DEPT NEUROL BALTIMORE MD 21205
Titolo Testata:
Journal of clinical psychopharmacology
fascicolo: 3, volume: 13, anno: 1993,
pagine: 214 - 217
SICI:
0271-0749(1993)13:3<214:RSEO(->2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
CENTRAL SEROTONERGIC NEURONS; RAT-BRAIN; MONOAMINERGIC SYSTEMS; MDMA ECSTASY; METHYLENEDIOXYMETHAMPHETAMINE; AMPHETAMINE; PSYCHOSIS; SYNAPTOSOMES; DERIVATIVES; TERMINALS;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
25
Recensione:
Indirizzi per estratti:
Citazione:
U.D. Mccann e G.A. Ricaurte, "REINFORCING SUBJECTIVE EFFECTS OF (+ -) 3,4-METHYLENEDIOXYMETHAMPHETAMINE (ECSTASY) MAY BE SEPARABLE FROM ITS NEUROTOXIC ACTIONS - CLINICAL-EVIDENCE/", Journal of clinical psychopharmacology, 13(3), 1993, pp. 214-217

Abstract

(+/-)3,4-Methylenedioxymethamphetamine (MDMA), a synthetic amphetamine derivative used recreationally by humans, damages brain serotonin neurons in experimental animals. In preclinical studies, serotonin reuptake inhibitors block MDMA-induced serotonin release; they also block MDMA neurotoxicity. Whether serotonin reuptake inhibitors also block MDMA's psychoactive effects in humans has not been established. Reportedherein are four individuals who describe their experiences after ingesting fluoxetine, a potent and selective serotonin reuptake inhibitor,before MDMA ingestion. Their reports indicate that fluoxetine does not block MDMA's reinforcing subjective effects and raise the possibility that MDMA's psychoactive effects may be separable from its neurotoxic actions.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 30/03/20 alle ore 00:29:53