Catalogo Articoli (Spogli Riviste)

OPAC HELP

Titolo:
SEROTONERGIC MANIPULATIONS IN EXPERIMENTAL NEOPLASTIC SPINAL-CORD COMPRESSION
Autore:
SIEGAL T; SIEGAL T;
Indirizzi:
HADASSAH UNIV HOSP,DEPT ONCOL,NEUROONCOL CLIN,POB 12000 IL-91120 JERUSALEM ISRAEL HADASSAH UNIV HOSP,DEPT NEUROL IL-91120 JERUSALEM ISRAEL CHOSEN SPECIALTIES CLIN,SPINAL CLIN TEL AVIV ISRAEL
Titolo Testata:
Journal of neurosurgery
fascicolo: 6, volume: 78, anno: 1993,
pagine: 929 - 937
SICI:
0022-3085(1993)78:6<929:SMIENS>2.0.ZU;2-N
Fonte:
ISI
Lingua:
ENG
Soggetto:
VASCULAR-PERMEABILITY; DEXAMETHASONE TREATMENT; FUNCTIONAL RECOVERY; EPIDURAL NEOPLASMS; EVOKED-POTENTIALS; 5-HT2 RECEPTORS; SMOOTH-MUSCLE; EDEMA; RAT; 5-HYDROXYTRYPTAMINE;
Keywords:
SPINAL CORD COMPRESSION; CYPROHEPTADINE; KETANSERIN; SEROTONIN; SPINAL CORD NEOPLASM; PARAPLEGIA; RAT;
Tipo documento:
Article
Natura:
Periodico
Settore Disciplinare:
Science Citation Index Expanded
Science Citation Index Expanded
Citazioni:
36
Recensione:
Indirizzi per estratti:
Citazione:
T. Siegal e T. Siegal, "SEROTONERGIC MANIPULATIONS IN EXPERIMENTAL NEOPLASTIC SPINAL-CORD COMPRESSION", Journal of neurosurgery, 78(6), 1993, pp. 929-937

Abstract

The effects of differing strategies of serotonergic manipulation on vascular permeability, prostaglandin E2 (PGE2) synthesis, and the clinical course are evaluated in an experimental model of neoplastic spinalcord compression in rats. Serotonergic manipulations include in vivo inhibition of serotonin (5-HT) synthesis by p-chlorophenylalanine (p-CPA) and in vivo blockage of serotonin type 2 (5-HT2) receptors either by the selective antagonist ketanserin or by cyproheptadine. In paralyzed rats, the ratio of 5-hydroxyindole-3-acetic acid (5-HIAA) to 5-HT is significantly elevated in the compressed segments, suggesting that 5-HT utilization is increased. Treatment with p-CPA attenuates spinal 5-HT levels by 62.8% +/- 5.1% (mean +/- standard deviation) and reduces the elevated 5-HIAA:5-HT ratio to the normal value. The increased synthesis of PGE2 observed in the compressed cord is unaffected by p-CPAor ketanserin treatment but is markedly attenuated by cyproheptadine. Ketanserin reduces the 10-fold increase in spinal cord permeability observed in paralyzed rats in a clearly dose-related manner. If given at the first sign of neurological dysfunction, ketanserin delays the onset of paraplegia with the 1-mg/kg dose being clearly superior. Cyproheptadine and p-CPA also reduce the increased permeability and protractthe course to paraplegia. A comparison of the effect of dexamethasone, indomethacin, cyproheptadine, p-CPA, and ketanserin reveals that they protract the disease course by 48%, 57%, 60%, 64%, and 78%, respectively. These data suggest that 5-HT2 receptors mediate some of the deleterious vascular consequences observed in the compressed spinal cord by a mechanism not coupled with PGE2 synthesis. A potential benefit of serotonergic manipulations for the acute treatment of neoplastic spinal cord compression is suggested.

ASDD Area Sistemi Dipartimentali e Documentali, Università di Bologna, Catalogo delle riviste ed altri periodici
Documento generato il 06/04/20 alle ore 01:48:43